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This episode included 4 minutes of scenes which were edited out from the version that aired on November 16, 2004. It was released in limited number in magazines, etc. to introduce the program to the viewing audience. A web site was set up by FOX so that viewers could log on and give their opinions of the program.
A young kindergarten teacher, Rebecca Adler, who suffers from seizures collapses in her classroom after uncontrolled gibberish slips out her mouth while she is about to teach her students. She is taken to Dr. House and his team of experts who identify it might be a tumor, and she might have only a week to live.
A college student collapses after rowdy sex with his girlfriend. While House and his team attempt to determine the cause, the student's condition continues to deteriorate and his symptoms multiply complicating the diagnosis.
When a virus is spreading among the hospital, infecting six babies, House and his team must make decisions that could compromise the lives of the babies.
A nun whose hands are red, swollen and cracked is sent to House. The nun believes it is stigmata, but House suspects an allergic reaction. He gives her some pills, which cause her to become unable to breathe. As her condition worsens, her fellow sisters pray for her while House and his team work to discover the cause of her illness while House has to wonder if he misadministered the illness.
Dr. House is intrigued by the symptoms of a schizophrenic woman, who displays mixed symptoms, including a tumor, but soon realizes the source of her problems isn't the obvious. House confronts his birthday and Chase confronts his past when the mother's son tries to keep up with her condition.
Two men are out jogging -- one of them returns back to his wife and discovers her dead asleep and brings her to the clinic. The doctors are puzzled by her symptoms. They consider everything from tumors to breast cancer to rabbit fever. When all the treatments fail, House concludes she has African sleeping sickness. However, neither the woman nor her husband could possibly have ever been to Africa. The woman will die without the proper treatment, but neither one will admit to having an affair.
When a high school student falls victim to a mysterious but lethal poisoning, House and his team jump in to find out what is killing the teen. Given a low heart rate and a clean tox screen, House sends Cameron and Chase to the teen's home to find the hot new drug House is sure he's taking. They don't find any drugs, but think they've come up with the answers, until a second unrelated student is admitted with identical symptoms. With the boys' lives hanging in the balance, House and the team have to connect the dots – fast. Meanwhile, an 82-year-old patient has become enamored with House while he helps her figure out the basis of her renewed fascination with her sexual feelings.
Legendary jazz musician John Henry Giles is checked into the clinic and when he's told he's dying from ALS, he signs a DNR to avoid a slow death. House disagrees with the diagnosis and goes against everyone's wishes when he violates the DNR to save Giles' life. The decision lands House in court, drives Foreman to consider taking another job, and results in Giles' paralysis worsening. But when the patient inexplicably starts getting better, the team has to figure out the mystery in reverse and find out why his condition is improving. Meanwhile, Dr. Foreman meets with an old friend who offers him a West Coast partnership.
Dr. Foreman believes an uncooperative homeless woman is faking seizures to get a meal ticket at the teaching hospital. But her homelessness strikes a personal chord with Dr. Wilson and he grows determined to keep her from falling between the cracks. Her worsening symptoms prove to be a complex mystery for House and his team, but the mystery of her identity and medical history may hold the answers to saving her life. Just as the team suspects she has contagious meningitis, the woman goes missing, only to be tasered by the police, who bring her back. But House deduces the taser may have proven yet another diagnosis, with dire results. Meanwhile, House has an audience of two medical students who are learning how to do case studies.
While trying to figure out why a young patient won't stop bleeding after a car wreck, House takes Cuddy's challenge and goes off Vicodin for a week in exchange for no clinic duty for a month. If House and his team can't determine the source of his patient's blood loss, the 16-year-old car victim will die in a matter of days. As House's withdrawal symptoms become more and more severe, his patient directives for his patient are more harsh and risky than usual, and Foreman and Cameron are afraid he may not be thinking clearly enough to save the patient's life.
A severely broken arm reveals a bizarre case of bone loss and ends the comeback plans of major league pitcher Hank Wiggen. House suspects Hank – with a history of drug abuse – is lying about using steroids, as his condition worsens. When Hank's kidneys start to fail, his wife offers to donate hers, but she would have to abort her early pregnancy. Forced into an impossible solution, and admitting failure as an addict, Hank tries to take his own life. House and his team must isolate and fix the problem soon if this pitcher's life, as well his career, can be saved. Meanwhile, Foreman dates a pharameutical representative and House is stuck with two tickets and ends up going on a "date" with Cameron...to a monster truck rally.
A 12-year-old boy believes he's cursed after a Ouija board tells him he's going to die, and his father makes increasing demands on House as they try to diagnose the boy's pneumonia-like symptoms and incongruous rash. Meanwhile, Chase's estranged father, a renowned doctor from Australia, visits and House invites him to sit in, much to Chase's discomfort. When House diagnoses the boy's illnees, the young patient is forced to face the idea that his father may not be everything he believes.
Billionaire entrepreneur Edward Vogel spends $100 million on the clinic and becomes the new Chairman of the Board. As a businessman, Vogler intends to turn the clinic into a profitable venture for his biotech venture and plans to eliminate the financially draining services of Dr. House. Meanwhile, a businesswoman who has it all – perfect life, perfect body, perfect job – finds herself inexplicably paralyzed. When he diagnoses her secret, House must risk his job and his medical license to get her a necessary transplant.
Just before mobster Joey Arnello spills the beans in federal court and enters witness protection, he collapses. Is he faking? A court order instructs House to find out – and fast. House and his team struggle to diagnose and cure Joey while Joey's brother Bill tries to slow things down and keep Joey from testifying. Meanwhile, Cuddy struggles to convince Vogler that House is an essential part of the hospital.
House must fire one of his doctors and leaves them to think about it while they deal with an overweight 10-year old child who suffered a heart attack as the result of taking diet pills. House is also faced with a woman who won't accept surgery for a 30 lb. tumor because she wants to remain overweight.
At a high-level campaign fundraiser, a senator becomes violently ill. Vogler forces House to take the senator's case and offers to let off the hook on firing a team member if he'll deliver a speech on behalf of Vogler's pharmaceutical company. It looks like the senator has AIDS but House refuses to settle for the easy answer. And House ends up giving the speech, but it doesn't go quite as Vogler planned.
While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is working to get House fired after House's pharmaeutical speech. House determines the illness, but the woman and her husband must struggle with an emotional and heartbreaking choice: choose between her or that of her unborn child. Vogler calls for a vote to remove House, but when Wilson refuses to make the vote unanimous, Vogler threatens to take his money if Wilson isn't voted out. Finally, Cuddy must take a stand against Vogler.
During an meningitis outbreak which overwhelms the clinic, House is drawn to a single patient: a 12-year-old whose symptoms don't quite match everyone else's. House, Foreman, and Chase must devise ingenious ways and locations to treat the girl's delicate condition in the middle of the chaos, and make an unexpected discovery. Meanwhile, House asks Cameron to come back to her job but she has one requirement that he might not be able to meet.
House apparently triggers a stroke in a clinic patient, but the major topic of discussion is House's imminent date with Cameron, The team must deal with the patient's odd lifestyle, overbearing "friend," and reluctant parents in order to stop the strokes and try to save his life. Meanwhile, Wilson, Cuddy and the team offer House and Cameron advice while laying odds on the outcome.
House's ex-girlfriend Stacy Warner returns – not for House but to get help for her ailing husband. While House decides whether or not to take her case, Cuddy forces him to present a lecture to a class of medical students. As he weaves the stories of three patients who all present with a similar symptom, House gives a lecture the students will never forget.
When Stacy insists her husband Mark get tests, House insists he can handle things. But despite the fact Mark's tests prove negative, his steadily growing symptoms indicate he is dying. While House struggles with the mystery and make increasing demands on his staff, Wilson worries about House's emotional well-being, and Cuddy considers adding a new employee to the clinic.
A death row inmate is felled by an unknown disease and House decides to take on the case, over Cuddy and Foreman's objections. House also has to deal with Stacy who is working closely with him, while Cameron has to cope with a dying patient.
Dr. Wilson convinces House to take the case of one of his patients, a young girl with terminal cancer who starts suffering from hallucinations.
An asthmatic man suddenly becomes unconscious and falls off of Dr. Cuddy's roof while working on her house.
While in Africa, a famous doctor becomes inexplicably ill and is sent to Dr. House for treatment.
A Princeton student who is graduating suffers a seizure while partying at a frat house. House's parents also drop by to see their son.
A professional bicyclist is brought in after collapsing during a race, but House doesn't want to treat him because he thinks the athlete is taking performance-enhancing drugs. House only becomes interested when the patient admits to taking the drugs.
A gay man with full-blown AIDS collapses in front of House's home and goes into shock. When House discovers the man's father is suffering from symptoms of his own, he must determine if they might be connected and save both their lives. Meanwhile, Cameron faces a potentially life-threatening disease of her own.
House and Chase find themselves in a serious situation after a young mother with stomach pains dies. Months later, Stacy counsels Chase prior to his disciplinary hearing, and must determine whether Chase made a mistake that ultimately led to the patient's death. She soon realizes he is holding something back.
With Foreman being House's supervisor, the team must figure out if a young girl who cried wolf too many times is really ill.
While attending his editor's retirement party, a journalist collapses and hits his head on a desk. When he regains consciousness, his sentences are garbled and incoherent, so he is rushed to Princeton Plainsboro Teaching Hospital. With House and Stacy stranded at an airport due to bad weather, the team is forced to solve the case with House helping out over the phone.
While the staff tries to diagnose a woman suffering from uncontrollable muscle flailing and crashes her car, House and Stacy try to resolve their relationship issues once and for all. Cameron refuses to get the results of her HIV test.
While a severely burned teenager is admitted and his blood tests come back with strange results, House makes himself the guinea pig in his own unofficial tests of a new drug designed to treat migraines to prove a former medical school colleague is wrong about the drug.
House uncovers a startling secret when he treats a teenage supermodel for heroin addiction. Meanwhile, Wilson hopes the increased leg pain in House's leg is an indication his leg nerves are regenerating.
House takes the case of a man who experienced a seizure, but wasn't aware it happened. When the man suffers a heart attack and needs a heart transplant, the team races to diagnose a dead woman's illness so they can harvest her heart to save their living patient.
House believes a woman is trying to kill her husband and tries to find the proof to confirm his suspicions. When Wilson moves in with House after separating from his wife, he learns Wilson is a great cook.
Melinda, a troubled teenage girl who is immuno-compromised as a result of the medications she must take after a heart transplant, has a severe allergic reaction and goes into shock when her boyfriend visits her. Meanwhile, House and Wilson continue to work out the problems in their new living arrangement.
When a six-year-old boy is brought in with the same symptoms as another patient who had died, House believes the cases are identical and he can predict the course of the boy's illness. Meanwhile, the hospital hosts a poker night to benefit the oncology department.
House has to work fast when a woman comes in with a life-threatening case of insomnia.
House treats a 15 year old faith healer, while Wilson feels left out when he finds out House has a weekly poker game.
When a police officer with a gunshot wound to the head and uncontrollable laughter is admitted, House and the team are baffled. When Foreman begins showing the same symptoms, they race to determine the cause of the illness before Foreman's condition takes the same path.
Foreman continues to experience the same progression of symptoms as the police officer. When he realizes he may be facing imminent death, he calls his father who comes to his son's side. As it comes down to a race against time, House believes the solution to the illness is in the police officer's apartment.
A young mother has a seizure while bathing her newborn son and nearly drowns him. House and the team have two cases at one time as they try to save the infant and determine the cause of the mother's seizures.
A 16-year-old Hurricane Katrina victim suffering from hallucinations as a result of the tragedy is brought to House by his former bandmate who recently found out the girl is his daughter. Although House fears his friend is being scammed, he takes the case. As he works his way through the girl's lies so he can diagnose and treat her, he's forced to tell a few lies of his own.
As House and his team are working on the diagnosis of a man with a giant, swollen tongue, a disgruntled former patient walks into House's office and shoots him. House continues to treat his patient from his ICU hospital bed with Moriarty, who had been shot by hospital security and hand-cuffed to his bed, as his roommate. When the after-effects of the shooting begin to impact House, he starts to question his own ability to diagnose properly. As his patient's body deteriorates, House struggles through his self-doubt and must trust his team to find a way to solve the case.
After recovering from his gunshot wounds, House works feverishly on two cases at the same time: a paralyzed man who drove his wheelchair into a swimming pool and a woman who became paralyzed after a yoga session.
House and the team treat a young boy who claims there is a tracking device in his neck and believes he has been the subject of experiments by aliens. Cameron is outraged when she learns Cuddy and Wilson have been lying to House about the diagnosis on his last case.
Ezra Powell, a renowned pioneer in the field of medical research, collapses in his lab. House is struggling after the ketamine treatment wore off and doesn't want to talk about it. When the team put Ezra through rigorous diagnostic tests and don't come up with anything conclusive Ezra demands the team to help him end his life. Now the team goes through twists and turns of the moral dilemma of ignoring his wishes or to assist in his suicide and abide by Ezra's wishes.
House takes the case of Adam, a 10-year-old severely autistic boy who screams loudly for no apparent reason, at least not a reason his three previous doctors could diagnose. The team wonders why House is taking the case - the boy's not sick; his symptoms seem to be a product of his autism. House claims he just wants a patient who can't lie, but it seems he relates to this kid: the social aloofness, the obsession with detail, the lack of social graces. In fact, House actually envies him; living in a shell has its advantages. But when Cuddy makes a minor change to House's office and House refuses to use the office until it's returned to its original state, he finds himself wandering the hospital in need of a temporary home, crashing in Cuddy and Wilson's offices. Meanwhile, teenager Ali from the previous episode still has a crush on House and is becoming a nuisance around the hospital. As Adam becomes more ill and the torturous diagnostic procedures yield nothing, House realizes he needs an answer, and his patient just might be the only one who can give him one. House finds he has to break through the very shell he admires in order to get anything out of the boy.
House takes on the case of 20-year-old female patient Tracy Dawson, who is rushed to Princeton Plainsboro Teaching Hospital with breathing difficulties and unexplained intense abdominal pain after she and her husband, Jeremy, are victims of a robbery. During Tracys stress test, Jeremy collapses in the hospital viewing room, with test results leading the team to believe the couples illnesses are related. Their strained relationship with Jeremys father causes Tracy to hallucinate about a past incident when her father-in-law tried to hurt Jeremy for seeing her. The traumatic dream leaves Tracy in a coma and House wants to conduct a very risky biopsy on her brain stem, but Jeremy refuses to consent. House enlists Wilsons help to explain the potentially dangerous procedure and secure Jeremys consent, but all does not go as planned; House discovers a new symptom that takes the case down a shocking new path and changes the course of the couples lives forever. Meanwhile, House and clinic patient Michael Tritter (guest star David Morse) have a touchy altercation, leaving Tritter appalled and furious at the way House treated him.
The team encounters logistical problems while trying to run tests on a 600-pound man due to his extremely large size. Meanwhile, House spends the night in jail after being arrested by Detective Tritter for various charges, including resisting arrest.
House decides to awaken a comatose patient so he can question the man regarding the family history of his son, who may have a genetic condition and the father is the only living relative. Meanwhile, Wilson confronts House about the stolen prescription pad as Tritter approaches Cameron, Chase, and Foreman in an attempt to divide the team and reveal their loyalties.
An 18-year-old teenager is brought to the hospital after having a heart attack. House reviews the boy's file and believes he has the diagnosis. He then turns the case into a game by sealing his opinion in an envelope and challenging Cameron, Foreman, and Chase to guess House's diagnosis on their own. Meanwhile, Tritter's actions against Wilson continue to strain the oncologist's relationship with House and destroy his ability to practice medicine.
House takes the case of a young girl who has been diagnosed with pancreitis. When he takes her divorced parents to court to force them to allow treatment because they can't agree, the judge awards guardianship of the girl to Cuddy. Meanwhile, Tritter continues his strategy to force House to admit to his drug use by offering one of the team members a deal.
Wilson arranges for House to make a deal with Tritter, but House refuses. Meanwhile, Cuddy cuts House off Vicodin and removes him from the team's case: a 15-year-old little person who entered the hospital with a collapsed lung and anemia.
House splits his time between treating a firefighter for uncontrollable shivering, giving Tritter a piece of his mind, and handling his trial for forging prescriptions.
While House is forced to work full-time in the clinic and deal with a rape victim who insists on confiding with him, Cameron deals with a terminal cancer patient trying to take advantage of her state of mind.
House and his staff must deal with a teenage Gypsy boy suffering from inexplicable respiratory distress. However, House has bigger issues on his mind: Cuddy has given away his handicapped spot.
It's Valentine's Day, and Cuddy has a blind date. Meanwhile, House leaves ER duty to take the case of a child patient named Hannah.
House encounters a brain-damaged musical prodigy with inexplicable abilities while the team faces serious concerns about House's own health.
The ex-Marine that saved House's life, in a dream he had, is admitted in the hospital with symptoms resembling Gulf War Syndrome. While House is busy dealing with his own health issues, and Chase and Cameron are too busy with each other, the ex-Marine gets worse.
A famous celebrity photographer suffers from a stroke while being pregnant at her early forties. House and his team have to deal with a great dilemma, save the mother or her unborn child.
On House and Cuddy's flight from Singapore a passenger gets ill and Cuddy suspects an epidemic. At the hospital, Wilson leads the team as they deal with a middle-aged woman suffering from seizures.
A 6-year-old girl suffers ailments expected in patients much older. Tensions between Chase and Cameron lead House to intentionally assign them to the same tasks, including investigating the young girl's home.
The doctors try to find what's wrong with a scam artist who collapses after her brain "freezes," but the case becomes personal for Foreman.
Wilson prepares to transplant bone marrow from Matty to his brother Nick. But when Matty gets sick, the team must cure him as he's the only safe donor. Meanwhile Foreman deals with the consequences of his mistake and House has a battle of wills with his new pet Hector.
The team deals with a 19-year-old college student, while Foreman suddenly and without a reason hands in his resignation. House seems to have already found Foreman's replacement, an attractive nutritionist named Honey.
House treats a 16-year-old chess prodigy who gets everyone on the team annoyed with his behavior. Foreman is upset with House because he thinks his boss sabotaged his job interview with another hospital.
A Cuban couple attempt to get to America by raft... to see House about the wife's heart condition. But when she gets worse House wonders if someone on his staff messed up. Meanwhile Foreman prepares to leave and his departure threatens to shake up the entire team.
With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hire a new team, but instead attempts a differential diagnosis with help from the janitor.
House is secretly trying to treat a fighter pilot who is a candidate for NASA's astronaut training program. Her diagnosis will be the test to choose which ones of the 40 applicants are going to take the empty spots in his team.
The candidates are now two teams of five women and five men, competing on diagnosing and treating a wheelchair-bound man. Meanwhile House does experiments on himself to test what happens after death, and Foreman, at another hospital, is treating his team in a House-like manner.
House finds that some of his own fellowship students will do whatever it takes, when they deal with a woman who believes she can talk to the dead.
House deals with a patient who mirrors the personality of anyone he meets. Meanwhile, Foreman is put in charge of overseeing the fellowship candidates.
Based on practically no information and no medical history about a mystery patient sent by the CIA, House is using some unorthodox methods to diagnose and treat him. Meanwhile the remaining candidates are questioning Foreman's judgment.
A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart attack prior to a serious plastic surgery.
House treats a magician but comes to believe he's faking illness to cover up his own incompetence. Meanwhile, House pits the fellows against each other in his version of an immunity challenge.
Under Cuddy’s pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user. Whoever diagnoses the patient is going to have a future as a member of House’s team.
A mother's sudden paralysis during a indoor rock-climbing incident leaves her daughter injured, and House's new team looking for a cure. Meanwhile, House organizes his new recruits' Secret Santa gift exchange... with a few twists of his own.
House and his team have to diagnose a case at a distance when a researcher at a South Pole base is taken ill.
House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.
House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy's orders to give performance reviews, and fighting with Amber over who gets to spend more time with Wilson.
House treats a famous soap opera star when he believes the patient has a serious condition even though there's no evidence indicating that's the case. Meanwhile, Wilson and Amber have their first fight.
A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who it was, and what they had.
In the aftermath of the bus accident, House struggles with his head injuries and short-term memory loss, and must remember the symptom he saw before one of their own, who was on the bus with House, dies.
Patty Mishner, the head of Woman's Majority, arrives at a company meeting with her assistant Lou to give them advice on how to deal with women's issues. As she talks to the board, Lou starts hallucinating being covered with ants and starts ripping off her clothing. House is in the coma patient's room playing video games and ducking Cuddy. She finds him anyway and tells him that Wilson's back. House says Wilson wanted time alone and left him to himself. Foreman arrives and informs them about Lou's case. Cuddy suggests someone else takes the case, but House takes it rather than talk to Wilson. The team meets and goes over Lou's travel history and the possibility she's taking amphetamines to keep up with her job. Taub suspects a B-12 deficiency due to work pressure but Thirteen believes she has cancer and doesn't think it's work-related. House jumps in and talks about her having Huntington's Chorea, then backs Taub's diagnosis and orders vitamin treatments. Afterward, the rest of the team approaches Thirteen, who denies having Huntington and accuses House of deflecting his problems into her. Lou is on the phone talking with her boss when Thirteen arrives to give her vitamin boosters. Lou suddenly says she's had a bowel movement, but Thirteen realizes she's bleeding anally. House goes to see Wilson, who says that he's leaving. House suggests that emotional pain fades away but Wilson doesn't believe it. When Thirteen informs him about Lou's condition, House sends her away and tells Wilson to get over the textbook grief reactions. Wilson cuts him off and leaves. Thirteen and Taub conduct a rectum probe and Thirteen isn't thrilled with House putting his personal issues before the patient. They don't discover a source for bleeding but Kutner reveals that the pre-procedure test for pregnancy showed positive. They administer an ultrasound to Lou who defends her choice to relieve her needs. However, they find no sign of a fetus. They go to House and confirm the B-12 treatments are kicking in but Lou's heart is still slowing. House tells them to go ahead and confronts Wilson again and tells him that he's suffering too. Wilson doesn't take that well. The others come in and Wilson informs them that he's leaving. House focuses on the case again and goes to see Lou. He mistakes her for being age 27 instead of 37 because of her good skin, then administers another ultrasound. He determines the fetus descended into her intestines and orders surgery to remove it. Thirteen confronts House, insisting they should try to save the fetus. He refuses and questions her judgment and thinks the knowledge of her condition is coloring her decisions. Thirteen goes to Lou, who is fine with having the fetus removed. Meanwhile, House goes to see Cameron and suggests she talk to Wilson because she lost her husband. Chase starts the operation, but Lou's blood pressure starts dropping and they just manage to stabilize her and remove the fetus. House goes to Cuddy and suggests she block Wilson's references to other hospitals. Cuddy would rather House apologize to Wilson, but he refuses because he doesn't feel responsible for her death. She tells him to tell Wilson he feels like crap but he insists it's meaningless. Lou is now having neurological problems and flat lines, and they call House. House is in Wilson's office and asks if apologizing would change anything. When Wilson refuses to consider it, House states that he'll go home and ignore his patients until Wilson agrees to stay. As Lou's condition worsens, House leaves the hospital. The team goes into differential without House, and with Cuddy supervising. She tells them she's confident in their abilities and leaves. Thirteen suggests MS, which matches all the current symptoms, and Foreman authorizes interferon treatment. Cuddy goes to see House and point out that he's running away as well, but House closes the door in her face. Lou regains consciousness and wants House to treat her. She insists she'd be nothing without Patty and when Thirteen objects, Lou admits that not everyone is equal. She starts to shiver due to fever, disproving the MS diagnosis. House comes back to the hospital to confront Cuddy because she's managed to disconnect his cable. She's also taken the doctor's lounge remote, and called Wilson in on a fake emergency. She refuses to give up his salary history or give House cable access until they both sit down and work things out. The team goes over the recording of the surgery and Kutner spots a possible ganglioma that could be causing the symptoms. They decide they'll have to open Lou up again and determine exactly what is it. Meanwhile, House and Wilson aren't interested in talking about anything except Cuddy. She finally tells Wilson he can't run away and he storms out, noting that no one at the hospital liked Amber. Chase believes the lump was a hematoma which is why he ignored it during the surgery. He refuses to operate, insisting that Lou won't survive a second round of anesthesia. Thirteen insists he would agree if it was House, but he notes they're not House. Kutner comes up with an alternative: inserting a lighted probe up her rectum and finding the lump, then pushing it up to the skin and removing it. Thirteen informs Lou about the procedure, and the assistant reveals that she was fired. Thirteen wonders how Lou can let Patty treat her that way, but Lou has no problem with it and admits she'd rather aspire to greatness then achieve it. They go ahead with the procedure and cut out the suspected ganglioma. Meanwhile, Cameron talks to Wilson and warns him that he's not making a rational choice even if he thinks so now. She admits the pain eventually gets easier but never goes away, and he can't handle seeing anything that reminds him of Amber. She says she has the same problems with her dead husband even now, and warns that there's no "right" choice to make. They determine that the lump is not a ganglioma, but indicates amyloidosis. They don't know what the cause of it is and have to determine it or she'll never leave. They all disagree on the cause, so Foreman takes the information to Wilson. He suspects lymphoma, confirming Thirteen's guess, and Foreman orders chemo. He tells Wilson that he should leave: everyone else would and anything that might make his life easier would help. Thirteen talks to Lou as she receives chemo. Lou says she's feeling better and says that Thirteen might be able to aspire to more. In response, Thirteen explains she has Huntington's and she wants to make her life matters before it runs out. Lou admits that Thirteen has inspired her and she's applying for a job at a foundation. House has obtained the nurse's remote and is preparing to watch his soaps. Cuddy asks him why he thinks Wilson is leaving, and then says she hoped he would say something insensitive and… true. She figures he's afraid to learn why Wilson is really leaving. House is thinking about something else: he goes to see Lou and notes she know looks like 37. He tells them to stop the chemo and takes a sample from a bruise on her leg. He reveals that she has diffuse lepromatous leprosy, acquired when she was traveling overseas. The symptoms include smooth skin, explaining why Lou looked 10 years younger. He orders antibiotics and leaves for his soap opera, and Thirteen is irritated that House was right. Later, Thirteen talks to Lou, confirming House's diagnosis. Lou admits that she's going back to work for Patty and she doesn't want her to change: she's happy being an employee rather than an employer. House talks to Thirteen later: she considers Lou an idiot but House notes that only dying changes everything. Realizing what he's said, he goes to Wilson… and apologizes. Wilson admits he doesn't blame House, and even tried to find something to blame on House. But he warns that they're not okay: he's leaving because he's tired of enabling and protecting House. They're not friends any more… and Wilson wonders if they ever were.
Two women are playing tennis when one of them collapses, clutching at her chest. On a construction site, a crane worker dies in his seat. A kickboxer dies in the middle of a match. A tuba player starts vomiting blood in the middle of a rehearsal and expires. Thirteen arrives at a college class and informs the math teacher, Apple, that she had a corneal transplant five years ago, and four other people who received a transplant from the same donor died. Apple is taken to the hospital where they determine four of the victims are dead and one more, an elderly man named Frank, is on the verge of death. The team is unable to determine a common denominator and House is more concerned about Wilson's absence. Finally House goes with a diagnosis of cancer and orders them to run more tests. He then heads for the cafeteria where he approaches Dr. O'Shea as a possible Wilson-replacement. Things look potentially promising until O'Shea refuses to go home with House to watch TV that night. Foreman arrives to inform House that Apple's eye is failing and they have to remove it. Apple starts hallucinating that House plans to decapitate her, indicating something is wrong with her brain. House goes over video of the kickboxer looking for signs of brain damage. The janitor interrupts to berate Taub and Kutner for being idiots, but they soon notice that he's wearing the wrong type of socks. They conclude he's a private investigator and House admits he hired him. The detective, Lucas, has already put together the information about the dead individuals that they need. Even House is impressed at his thoroughness. They need to do a biopsy and appeal to Frank's wife for approval, and Apple adds her urging, lying that she has a family. Taub reluctantly tellsFrank's wife the truth. Frank stops breathing ad dies despite Taub's efforts. House orders him to save the brain so they can do an autopsy. They determine Frank's brain is clean and House still suspects cancer. Foreman accuses House of suggesting cancer so he has a reason to call in Wilson. Kutner suggest a perforated intestine and bacterial infection that spread through the blood and infected all the organs. Houses a DNA check via a colonoscopy on the donor's daughter. House meets with Lucas, who figures that House wants him to hire him to check out Wilson and see if there's something House can use to get Wilson to come back. House asks if there is something, and Lucas admits there isn't. House returns to the hospital where Kutner and Foreman improve him the colonoscopy proved clean. House still believes in cancer and Kutner suggests they use a high-pressure water jet to apply pressure to Frank's colon. There are no leaks but Foreman spots what appears to be a core lesion. Kutner increases the pressure and Frank's intestines and body wastes spray out on Foreman. Apple's heart starts racing but there's no indication her colon is leaking. The team has nothing new and House orders chemo for the cancer he suspects she has. He goes to her room and signals an emergency when he can't find the medical records on Apple's bed. He then asks Apple to sign a consent form to receive chemotherapy, noting that he can't tell her she has cancer because then she might think the treatment is working. Nonetheless, he hints she has cancer. As she signs, Apple talks about how she was an architect but gave it up after her corneal transplant. She notes that she thought her life would be better once she saw, but nothing improved and her parents were still dead. Apple notes that House doesn't seem much different, and he notes that at least he hasn't given up. Lucas reports in to tell House that Wilson has a new job. He points a woman out that he's following because he likes her, then informs House that Wilson is attending grief counseling and Cameron and Cuddy have been at his house several times. Lucas starts following the girl and House has to trail along. The girl finally confronts them and says they're making her uncomfortable. After she leaves, Lucas notes that Wilson hasn't said anything about House. House gets a page and heads to the hospital where Apple is vomiting from the chemo but her system is stabilizing. Foreman is surprised House was right, but House concludes that it isn't cancer. Back in differential, House notes he never thought it was cancer but thought it acted like cancer. Now he wants to find something that is similar to cancer, and notes the last patient was using an anti-cancer medicine for his arthritis and it didn't save him. He goes to Wilson and asks for an epiphany, wanting to bounce ideas off of him. Wilson tries to shut him out and House asks how he's doing. Wilson begs him not to do this so he can move on, and House accuses him of talking to the others. House admits he hired a private detective to watch Wilson because they're not friends any more, then tries to run a diagnosis. Wilson refuses and warns he won't answer the door the next time House knocks. Lucas is outside and tries to advise House on friendship… and gives House an idea. He goes to see Cuddy and shows her Apple's CAT scan. It indicates something is in there that her brain isn't compensating for. House believes that the donor had cancer stem cells that attached themselves to the donor's various organs, and when transplanted eventually gave out and stopped working. He wants to open up Apple's skull before it's too late for her, and Cuddy wonders if House is going to do something to make Apple crash prematurely. She puts guards on Apple's room and House calls Lucas to have him sneak in and tamper with Apple's IV. She crashes and goes into surgery where they have to open up her skull. House suggests they check her IV and Chase figures he switched the meds but has little choice but to continue. They attach a neural net while Lucas comes into the observation gallery and realizes that House lied to him about how dangerous it was for Apple to switch the meds. The neural net will detect her nerve impulses and show them the problem. They spot the defective brain cells and remove them. Later, House goes to visit Apple and explains that the world is ugly but not as ugly as she thought. Her brain wasn't working properly and the transplanted brain cells were making things dull and unattractive to her. He takes off the bandages and Apple sees the world for what it is… and notes that House looks sad. House is in his office and calls to put Lucas on retainer.
Brandon, an artist, is doing a nude portrait of a woman as her husband looks on. He completes the painting and the couple look at it… and draw back in horror. Brandon doesn't see what's wrong with the portrait, but the husband punches him. Brandon's wife Heather comes downstairs as the couple leaves and shows Brandon the portrait: the wife's face is distorted. House meets with Lucas in the cafeteria to get his report on the staff when Cuddy comes in and wants to meet the person House is paying out of the hospital funds. Cuddy refuses to pay for House's detective. In the staff room, the team goes over Brandon's recent work which shows no other distorted portraits. Foreman suspects visual agnosia and Thirteen believes drugs are involved. House is more interested in revealing what he's learned about Kutner and Thirteen. He admits he doesn't have anything on Taub, but he does have info on Taub's wife. House refuses to say what and goes with the diagnosis of a tumor and prepare tests. Brandon is nervous at having them do tests and insists he's feeling better, but reluctantly gives in. Meanwhile, Kutner and Taub check Brandon's apartment but don't find any toxins or drugs. Taub says he doesn't care what his wife is doing. The tests prove clean and House hears that Brandon is worried about the tests. He concludes that Brandon is enrolled in drug testing to make money to keep up appearances for his wife, since he can't sell his paintings. Brandon admits that he's enrolled in the three drug trials but his system should be clean now. He tells Thirteen to find out what the drugs are and goes back to his office, where Taub is there and finally asks what House knows. House says that Taub's wife Rachel is putting $83,000 in a secret bank account, but Taub says he knows and it's going into renovations for their home. House is skeptical, but they're interrupted when they get a page that Brandon is having a seizure. None of the drugs cause seizure but House assumes that some mix of the drugs are responsible. House orders dialysis to clear Brandon's system for sure. Taub administers it and Brandon is worried that Heather might suspect something and wants to cover up the dialysis. Thirteen realizes that Taub is lying, but Taub doesn't see a reason to bring it up with his wife. The next morning, Taub reports that the dialysis is apparently working and House wants to know if Taub has told his wife. House then checks in with Lucas via a hidden radio headset. Lucas is camped out in the lobby and Cuddy notices him. The detective wonders why House is so interested, and if Taub's marital problems will make him work harder, or quit. Meanwhile , Brandon's throat and face swell up and Foreman has to do an exploratory tracheotomy. They administer steroids and cream to reduce the swelling without success. House still believes the mix of trial drugs is responsible and the new symptoms are from withdrawal. House suggests they detox him more effectively by readministering the drugs and then weaning him off them slowly. Cuddy confronts Lucas in the lobby, only to find out that the detective has paid someone who looks like him to sit there. She finds Lucas in her office, going through her drawers. He says he's doing it for free because he's interested in her but hasn't found anything. As he leave, he offers to give her interesting information about House in return for the chance to talk to her. At home, Taub and wife are having supper when he finally confronts her about the bank account. Embarrassed, she admits that she bought him the car he always wanted. Meanwhile, Thirteen monitors the drugs in Brandon's systems… and he grabs her and yanks her onto the bed. She punches him to get free . Now that the drugs are cleared out of Brandon's system, the team goes back to differential to find new theories. Taub admits that he asked his wife what was going on and demands an apology to House. House kind of apologizes… and then wonders why Rachel would give Taub a car. House goes orders Taub to stay the night and conduct tests. Then House goes home and finds Lucas in his closet trying to find something embarrassing to give Cuddy. House wants Lucas to find something on Cuddy for future negotiations and Lucas agrees. Kutner and Taub find narrow blood vessels and Taub believes that Brandon recently acquired a heart arrhythmia due to the drugs, and the narrowed blood vessels are causing the symptoms. House tells them to test Brandon's heart for arrhythmia. As they proceed, Taub tells Brandon he shouldn't confess to Heather if he's doing it to make himself feel better. They test the heart while Taub wonders when House will let him go home. Brandon's heart goes into overdrive and they're forced to stabilize it, but House is more interested in the fact that Brandon's hair is growing in red. The new symptoms suggest Romano-Ward Syndrome… except for the melanin change. They need to do a cardiac sympathectomy but they're not sure if Brandon's heart is stable enough to handle the operation. Lucas goes to Cuddy with a photo showing that House was a cheerleader in college. In return he gets to answer her personal questions. However, he realizes that she knows it's a fake photo. He admits he likes her because she's hot and smart, but he wonders why she isn't suspicious of the photo. He figures she must know it's a doctored photo, which means she knows it's a game. He apologizes and starts to leave, then concludes that since she knew he wasn't going to give her anything worthwhile, she must really be interested in him. Satisfied, he sits back down with her. Thirteen and Taub explain the procedure to Brandon, but he suffers from vision agnosia and mistakes them for someone else. House believes the agnosia is irrelevant and they still need to do a sympathectomy. Taub wonders if Brandon is suffering from a toxin from contaminated paint a year ago that got into his fat cells, and is being released as he loses weight at the hospital. House gives Taub an hour to prove his theory. Taub goes to Brandon and tries to talk to him alone, but Heather realizes something is wrong and insists on hearing the truth. Brandon tells her how he's been making money from drug trials, then concealed it from her to maintain her image of him. She insists that she loves him for who he is, and he tells Taub where the unsold paintings are. As Chase prepares to perform the sympathectomy, Taub finds the paintings and determines that Brandon suffer from agnosia while painting only some of them: on the odd months. Those were the months Brandon was on the trial, but can't account for the symptoms now. House realizes that Brandon was taking antacid before he took the drugs. He calls the operating room and tells them to conduct abdominal surgery to remove a bezoar. Taub explains to Heather that there was a buildup of food that formed in Brandon's stomach and absorbed the drugs, then started releasing them. With the bezoar removed, Brandon is fine. Taub asks Heather if she's happier knowing the truth, but before she can answer Rachel arrives to show Taub his car. He sees it… and then says they need to talk. Lucas is playing the piano at House's apartment when House arrives. The detective explains that Cuddy didn't accept the photo, and he didn't get anything on Cuddy. Lucas has checked out House's college on the Internet and discovered that the photo was real. He figures House to see Cuddy differently, and she didn't believe it and couldn't even conceive it was possible. As they play a duet, Lucas suggests he back off from romancing Cuddy and House jokingly asks if he would.
At a Buddhist temple in China, a woman, Nicole, and her translator approach a couple trying to obtain some birth information about her. They say they have no daughter. With no other choice, Nicole makes a wish which involves lifting a Buddha, making a wish, then trying to lift it again. If the wisher can't lift it the second time, the wish will come true. Nicole can't lift the Buddha the second time… and collapses, vomiting blood. House arrives for differential after Nicole is brought to the hospital, and is going over information on his co-workers when he's informed that his mother called, twice. House already knows she's calling about the fact his father died but says he's fine and starts on the case. Taub suggests that House call but House has deduced that he told his wife about his affair. House finally checks in with the patient, and her adopted parents come in. They've brought Nicole's medications and are concerned about the fact she's still drinking heavily. As House goes through the medications, he discovers licorice root and concludes that the Chinese doctors were treating her for SARS, which accounts for all of Nicole's symptoms. Cuddy comes in to House's office to offer her condolences and administer IG shots for everyone who came in contact with Nicole. She already has a flight scheduled for House, and informs him his mother wants him to give a eulogy. Nicole's birth parents have brought her adopted brother and sister there and Kutner treats her while treating her for SARS. She wonders if House is okay from being in contact with her… and in his office, he collapses. Meanwhile, Nicole crashes and Kutner realizes her liver's failing and it's not SARS. House wakes up to discover he's in a car… with Wilson driving. House realizes that Wilson drugged him after House's mother called him, not Cuddy. Wilson claims he's not doing it because he cares, and keeps House down to one Vicodin, enough to keep him on a leash. House gets a call from the team and Wilson reluctantly lets him take it. Nicole had a clot in the hepatic vein and they sucked it out. Thirteen insists that Nicole is a smoker and drinker, which combined with a genetic defect would account for the clots. Kutner goes to treat Nicole, only to find that she's gone. Meanwhile, House needs to pee and Wilson offers him a bottle. House calls his bluff and Wilson pulls over to a rest stop, but refuses to give him his cane. House starts to reminisce about the summer his father refused to talk to him, but refuses to lie to his mother by going to the funeral. House asks for his cane in return for the funeral and Wilson agrees. House promptly smacks his hand, knocking the keys into the sewer. Kutner finds Nicole outside smoking. She asks for five minutes alone but he declines and starts taking blood. Nicole admits that she feels isolated by being adopted by a white family, and Kutner notes he was as well. As he starts taking blood, she starts bleeding uncontrollably and he gets her back inside. Stuck at a rest stop, House talks more about his abrasive father while Wilson gets the keys out of the sewer. Wilson isn't interested in hearing about it or providing any support or enabling. Meanwhile, Cameron is picking out a bouquet to send on House's behalf, and Foreman suspects Nicole has a tumor. Chase doesn't believe that House is okay with his father's death. On the road, Wilson also believes that House has feelings, until House claims he was adopted. He lays out all the deductions he made to conclude that his father isn't his birth father, but Wilson assumes he's deflecting again. When he spots a cop car up ahead, House jams his cane onto the accelerator and they get pulled over. Taub and Kutner run a CT scan on Nicole and discuss Nicole's adoption. Taub figures that Kutner likes her, but they spot something unusual on the scan. Meanwhile, Wilson lied to the police about the fact House got him pulled over. The team calls House and reveals they've found a mass on the pancreas. The officer orders Wilson out of the car and handcuffs him, then orders House out as well, interrupting his attempts to differential by making a metaphor about steamrollers. They reveal there's a warrant in Louisiana for Wilson's arrest. The team tries to decipher House's steamroller metaphor, and Taub tries to get back to House or Wilson. House and Wilson are at the station and the police refuse to let him take his call. Wilson accuses House of not taking care of the charges of assault and vandalism at a medical convention in New Orleans. When Wilson mentions House is trying to avoid the funeral, Sheriff Costello takes an interest. Foreman meets with Cameron and Chase to try and decipher House's reaction to the information on the pancreas. They conclude she has gallstones… at the same time that the rest of the team figures out House's metaphor indicated gallstones. Wilson explains how he got into a fight over a jukebox song and after Wilson broke a bottle, House bailed him out so he'd have someone to talk to. Costello releases them, much to House's dismay, and tells House to go pay his respects to his dead father. Chase prepares to remove the gallstones but discovers that Nicole's urine is brown: her kidneys are failing and it's not gallstones. Back on the road, House contacts his team and informs them he didn't mean gallstones. He explains it's a multiple cysts connected to all the related organs. Thirteen suggests injecting bubbles into the cyst to see where they go. Wilson finds the funeral home. Meanwhile, Nicole starts to go through the DTs. Blythe House greets her son and asks him to do the eulogy for her: her husband's dead and there's nothing more for House to be angry at. Wilson is skeptical. Meanwhile, Kutner explains to Nicole's adopted parents that they'll need to paralyze Nicole, which will also get her through the DTs. Nicole's parents say they've supported her all along and Nicole admits she's given up on trying to get over her addictions, but Kutner says they need to worry about making her well first. House still refuses to give the eulogy or acknowledge he has any issues. House spots the man that he believes is his birth father, and admits to Wilson that he informed his father about his deductions, which is why he didn't' speak to House for a summer. Blythe addresses the mourners and asks House to come up. After a few seconds, House finally gets up and says a moving eulogy… and takes a skin sample. Wilson has a whispered conversation to tell him to stop, but House refuses to give in. Wilson pulls him into the next room and House points out that Wilson enjoys it. He notes that Wilson isn't ready for the worse, which is why Amber's death hit him so hard and made him angry. He accuses Wilson of being afraid that he'll lose House, and Wilson finally gets mad enough to break a bottle… again. Later, House and Wilson go to a diner and House explains that he saw Wilson carrying a package at the medical conference: a package containing his first wife's divorce paper. House calls the team, who has discovered that Nicole has an advanced dilated cardiomyopathy. There's a mass in the left atrium but they can't confirm because the image is grainy. House concludes that it's iron overload, and the iron is causing the grainy image. He tells them to do a MRI to confirm and then asks them for a phone number. House calls Nicole's translator in China and gets a description of the birth parents. The translator says that he doesn't believe the couple was Nicole's birth parents because of their reaction: the mother was frightened. House goes over the issue with Wilson, who realizes Nicole was born in 1983 but China introduced the one-child policy in 1979. They wanted a son and had a daughter instead. The parents tried to kill her and the father took Nicole to an orphanage without telling his wife. They conclude she was given something toxic that was fat-voluble. House gets back to the hospital where it turns out the team didn't go through with the MRI because Nicole started vomiting. He notes that her attempt to lift the Buddha brought on her illness. He orders them to stop the MRI and then uses an x-ray to determine there are pins in Nicole, from her birth father's attempt to kill her. The monks at the temple have the Buddha statue rigged with a magnet to keep people from lifting it a second time. The magnet moved the pins in her brain and triggered her symptoms. Once they remove the pins, Nicole will be fine. Kutner tells her adopted parents and they ask him not to tell Kutner that her biological parents wanted her dead. Kutner reveals that the pins have been pressing on her addiction symptoms, causing her smoking and drinking over the years. Wilson goes to see House in his office and finds him drinking. He shows Wilson the genetic tests: John House wasn't his birth father. House admits he's depressed that it doesn't make any difference to him, and Wilson wonders if anybody gets to choose anyone, as their parents… or as their friends. Wilson says he's coming back because House is right: he likes being around House, and their trip was the most fun he's had since Amber died. They head out to grab something to eat… and House acknowledges that his dad's dead.
Thirteen brings a woman, Spencer home with her and they have sex. Afterward, Thirteen goes to the bathroom and talks to Spencer in the other room. They're interrupted when Spencer falls out of bed, convulsing. Thirteen calls the EMTs who take Spencer to the hospital ER where Cameron admits her. Thirteen admits she doesn't know Spencer's name. Cameron brings the case to House, but he's busy playing a practical joke on Wilson. He goes into Wilson's office and finds him lying on the floor. House asks why Wilson was late and he claims he was meeting with someone for breakfast, but then eats a doughnut. Ecstasy doesn't account for the symptoms and House discovers that Thirteen knows about the case because she was with Spencer at 3 a.m. In differential, House is interested in Thirteen's downward spiral and whether she was using drugs. Thirteen insists that Spencer has visited four other doctors who have found nothing, and she's just a hypochondriac who drinks too much. House orders Thirteen to take a bone marrow sample and goes along with her. Spencer cheerfully talks about her sexual affair with Thirteen. House wants Lucas to investigate Wilson, noting he never eats a doughnut after a big breakfast. Lucas figures House is worried that something changed, but House tells him to check Wilson out. Thirteen has discovered letters from Spencer to the hospital, and realizes she used her to get to House for treatment. Spencer admits she didn't expect Thirteen to be so aggressive. Thirteen prepares to discharge her but Spencer has a respiratory seizure. House now believes drugs are involved and Thirteen realizes that her place will need to be searched. She figures House will come up with a reason for her to stay there while he searches her apartment. She refuses to give him her keys so House takes Foreman. However, House has had Lucas make keys of all his team's apartments and lets himself in. House denies having Foreman investigated or having his key, then heads for the bedroom. Foreman notes that House knows very little about him. Foreman picks up a letter and pockets it while House finds no sex toys, indicating she doesn't have regular sex partners. He also finds an asthma inhaler and a spider. He shows the team the spider and notes the venom can cause respiratory problems. House also reaches into his pocket and removes the inhaler. Thirteen seems concerned until she sees what it is, and House figures she has something more incriminating to hide. House orders Thirteen to check Spencer for spider bites. Thirteen says she wasn't interested in anything other than a one-night stand, but Spencer flirts with her and suggests there was potential. They start to kiss but Spencer can't feel Thirteen's hand on her hips. Thirteen reports the new symptom to House and the fact she has low potassium that indicates kidney problems. House proscribes surgery to remove calcification from the kidneys and confirm the diagnosis. House and Lucas watch Wilson as he plays video games in his apartment. Lucas spots an attractive blonde going into the apartment and to Wilson's door. House doesn't believe it but Lucas notes that things change. As Taub and Chase find the calcifications, Foreman talks to Thirteen and gives him the letter. It reveals she has less time then they thought and suggests she should be working out. Thirteen insists she's busy having fun and cramming as much into her life as possible, and dismisses Foreman's concerns. On the operating table, Spencer has breathing problems but they can't find anything in the lungs to indicate problems. They wonder if the airway collapsed and House orders a treadmill test. Thirteen is administering an IV to herself when Cuddy comes in. Meanwhile, Foreman discovers from his family that House had Lucas investigate him. House admits he didn't find anything… because Foreman hasn't done anything interesting since he was 17. Cuddy calls House in to inform him that she wants Thirteen to take a drug test or undergo suspension until she agrees to. House refuses to let Cuddy test his team and escorts Thirteen out… then tells her she's fired for failing at her duties. He then visits Wilson to get caught up. Wilson admits that he met someone new: an ex-prostitute. She wants to go to law school and he plans to help her with her tuition. House is skeptical and Wilson notes he's not in any position to be judgmental. House wishes him well and leaves. Thirteen is going over Spencer's case trying to find something to impress House with when Foreman comes in. He still thinks she's acting stupid. She finds a dark spot on the x-rays that indicate a cyst. She goes to where Spencer has just collapsed on the treadmill when one of the cysts burst and revives her just in time. House meets with his staff and orders the team to biopsy the cyst… and tells Thirteen she's still not going to be on the team. He then meets with House and tells Lucas about Wilson and the prostitute. House wants Lucas to find something on the prostitute to get her to back off. Taub interrupts them with the results of the lung biopsy. House then goes to see Thirteen as she packs to leave and points out that she has sex with women to control them, so she can get close to controlling herself. He then shows her Taub's report, which shows that Spencer has LAM and has no more than ten years to live. He suggests that Thirteen give Spencer the news, even though it has no bearing on getting her job back. She agrees and gives Spencer the news. They've removed the cysts, but they'll inevitably grow back. Thirteen describes what she'll go through and Spencer realizes she's dying as well. However, as Thirteen leaves she sees that Spencer is blaming due to anemia. Thirteen tells the team the symptoms and asks for the chance to work on the case. Anemia eliminates LAM, but they have nothing to work on so House orders tests for everything. As he runs the tests, Foreman asks Chase if he's boring. Chase says that he is, and that he never takes chances or puts himself at risk. Meanwhile, Thirteen holds Spencer's hand, then gets into bed and they kiss. House insists that Spencer needs a bone marrow transplant but Thirteen warns that she won't survive the graft rejection. House tells Thirteen tog et Spencer's consent, then returns to his office. Lucas is there and has Wilson's garbage, which contains drug syringes. House goes to Wilson and tosses him the garbage: he's figured it's Wilson's practical joke on him. However, House still wants to know where Wilson was the other morning. Wilson insists that it has nothing to do with House and they'll still be getting together regularly. House says fine, but Wilson realizes that House will follow him no matter what so he tells House where to find him that night. Thirteen gets Spencer's consent and House points out she's in a spiral of destruction that won't end until she's dead. However, until then he can use her: he gives her her job back. She realizes that he wanted her to spend time with Spencer so she could connect with someone. As she talks, House notices her cracked lips. Then he asks if Spencer cried when she got the news she was going to die. Thirteen says no and House grabs an onion and goes to see Spencer. He cuts the onion but Spencer still doesn't cry. House explains that she has Sjoegren's, which caused infections that led to the anemia. The cracked lips were caused by infection but Thirteen only has the infection, not Sjoegren's. Spencer will be okay. As Thirteen leaves for the night, Foreman congratulates her but she admits she feels alone even though Spencer is still there. Wilson goes to a baby store to help Cuddy pick out a crib. House has followed him and Cuddy explains that she's adopting a baby. Wilson was testifying as a character witness the other morning and Cuddy didn't want anyone to know until she received approval. She asks if House is going to congratulate her and he abruptly leaves. Thirteen has brought another girl home for sex.
Jerry Harmon is drinking coffee and wants his daughter Samantha to bring over a friend for her birthday. As she leaves for school, she tells him she isn't interested and leaves. Jerry tries to find some coffee but discovers that his five coffee machines are empty. He gets a can of coffee from the cupboard, turns, and finds them all gone. His daughter comes in and tells him that she's back from school: eight hours have passed without Jerry realizing it. He wipes his face… and finds himself in the living room with hours later and no idea how he got there. Cuddy brings the case to House as he arrives but he's more interested in pointing out that as a single mom she has little chance of adopting. She's going to see the baby but he concludes she's not defensive enough. The mother, Becca, is delivering in two weeks, and has used drugs in the past. House warns there's probably something else wrong and notes that Cuddy isn't equipped to handle a child. She leaves, telling him she's not changing her mind. The team goes over Jerry's case while House starts a pool on how soon Cuddy changes her mind. The team sticks with the differential and Thirteen wonders if he was exposed to a toxin and House has Thirteen and Taub go to Jerry's house, which has little decoration or ornamentation. Taub doesn't think single parents should have kids, including Cuddy, but he also believes the traditional family is a fraud. They find mold along the baseboard and takes samples. At the hospital, Thirteen tests Samantha for mold and the girl says that they have no friends or do anything outside of the home. She's indifferent to the death of her mother when she was four and says death is no big deal. Thirteen admits to Foreman that Samantha is weird, but as they talk they see Jerry waiting at the elevator. He keeps repeating that he has an appointment and has to go. Foreman checks his eyes and realizes that Jerry is asleep. In differential, the team considers the new symptom of sleepwalking and House prods the team toward an answer while claiming he doesn't have an answer himself. The mold doesn't account for the symptoms and House eventually suggests they send Jerry home and see what he goes for his sleepwalking appointment. Cuddy meets with Becca at a coffee shop and admits she hasn't thought much about the baby's name, although she's considering "Joy." Cuddy wonders why Becca chose her and Becca explains that her grandfather and father treated their wives badly, and Becca's boyfriend Tony treated her badly. She read Cuddy's bio and wants her child raised by someone who isn't a loser. Cuddy notices a rash on Becca's arms and the girl admits she's had overall joint pain. Cuddy insists on getting her checked out. Taub and Thirteen are watching Jerry when he starts sleepwalking and they follow him. Cameron checks Becca but doesn't determine anything worse than a heat rash. Cuddy orders additional tests but they show normal, and she admits Becca anyway and orders a full fetal wake up. House points out she's acting irrationally and then throws baby vomit on her. Cuddy goes to change her sweater and House points out that if she can't handle a stain, she can't handle a baby. Jerry is driving and Taub and Thirteen follow him in their car. He pulls up to a woman and exchanges something. They pull up to her but she tells them to leave, and Thirteen realizes she isn't a hooker. They catch up to Jerry and find him with cocaine. The team wonders how Jerry started sleepwalking before he took the cocaine. House wonders if Jerry forgot and whatever was used to cut the cocaine caused the memory loss. He tells Taub and Thirteen to buy cocaine from the dealer, Sadie, and test it. Cameron conducts an ultrasound and finds a pulmonary hypoplasia: undeveloped lungs. If the baby is born presently, it will die so they give Becca drugs to slow the labor. Cameron is forced to admit that Cuddy was right. Thirteen and Taub find Sadie and she sells them the good stuff, but Thirteen wants the poorer grade stuff the dealer gives to her regulars. Cuddy is packing when House visits her with some more insights. She's not in a good mood because of the baby's condition and he notes there's no such thing as unconditional love. House insists that the baby would be better for Becca because at least she knows she isn't a good mother. Cuddy orders him out and he gets a report from Taub that the cocaine was cut with lactose. House deduces that Jerry is lactose intolerant and orders them to give Jerry an allergy test. As Cuddy treats Becca, Becca figures the baby's lungs are because of the drugs and she wonders if Cuddy hates her. Cuddy notes that if Becca were perfect, she wouldn't be adopting the baby. Becca admires Cuddy's perfect life and then her heart rate increases and her placental wall breaks, causing vaginal bleeding. Cuddy describes the situation to House and he notes that if they deliver the baby now they save the mother but the fetus' lungs won't support life. If they wait, they put Becca at risk. House suggests Cuddy have Becca deliver now. When she agrees, he wonders if she's serious and told her the wrong answer. He points out that her motives aren't medical and some part of her doesn't want the baby. Cuddy insists she's telling Becca to take the safest route. House goes to Wilson for advice but Wilson figures House is doing it just to upset Cuddy, who is moving on with her life and growing up. House doesn't think much of his theory. Meanwhile, Taub checks on Jerry who can't believe he did coke. Taub suggests he isn't responsible but Jerry doesn't accept that. As he goes over the charts, Taub notices blood on Jerry's short: he's bleeding from his pores. The best diagnosis the team can come up with is leukemia and House orders them to do a bone biopsy. Cuddy advises Becca to wait, and the girl wonders if that's her opinion as a doctor or as a mother. Becca doesn't want to wait: she wants to be rid of the baby as soon as possible for her "stupid mistake." Cuddy says she should keep the baby to break the cycle of the poor parenting of her mother and grandmother, but Becca insists on delivering. Taub and Kutner take the bone marrow sample but Taub notices that Jerry's legs are tanned, meaning it's not leukemia. His kidneys are failing and his blood pressure is too low for dialysis. House orders them to test for vasculitis but Kutner warns that Jerry will need a kidney no matter what. House suggests they use one of Samantha's but they need Cuddy's permission since Jerry has an interest. House goes to the operating theater where Chase is removing the baby. House insists that Cuddy's place is acting as an administrator, not a mother. Cuddy insists on staying and after delivery, finally the baby cries. House congratulates Cuddy then tells her she has to go work. Cuddy goes over the procedure with Samantha but the girl is strangely apathetic. House refuses to proceed, saying he can't because Samantha is sleepwalking as well. They have to transplant to save Jerry but they can't risk it. Thirteen reports that the daughter has started bleeding from her pores and all they have left is a genetic disorder. Each test will take a week to run but they have no choice but to proceed. House talks to Wilson to come up with an idea but Wilson points out that House lost on the pool and since Cuddy adopted, she won't go through post-partum depression because her dopamine receptors weren't stranded. House gets an idea and visits the patients. He says they'll be fine and they don't react. He concludes that their anhedonic, unable to feel pleasure or happiness. Jerry took cocaine because he subconsciously wanted to be happy. House realizes they lied: he asks Jerry his real name and Jerry finally admits he's Jamal Hammoud: he changed it when the U.S. invaded Iraq. They have Familial Mediterranean Fever, which causes all of the symptoms. House warns the treatment is problematic but orders them to receive the medication. Cuddy paints the new baby's room that night while Jerry and Samantha receive treatment. In the morning, Jerry wakes up and is able to smile with happiness. A smiling Samantha is similarly recovered, and can now donate her kidney to save her father. Cuddy visits Becca and tells her the baby is doing fine. Becca admits she was selfish and remembers Cuddy smiling at the baby. She realizes Cuddy would have done the right thing and wants to do the same, and wants to raise her baby. Becca refuses to reconsider. As Cuddy looks longingly at the baby in the nursery, Samantha and Jerry share some happy moments together. Cuddy goes home and sits in the baby's room, alone, until House arrives. He says she can always find another baby but she doesn't want to go through the same thing again. He notes that she's giving up, again, and says she would have made a great mother. Cuddy snaps at her, noting that he's reversing himself again. He admits he doesn't know why he does it… and then they kiss. After a few seconds he backs off, says good night, and leaves.
Stewart Nozick is lying in the hallway of his apartment, the floor covered with rose petals. EMTs break in and administer emergency treatment, then put him on a stretcher and take him out. Once outside, Stewart panics and rips himself free, runs inside, and slams the door shut. Cameron tells House and his team about the case, including the fact Stewart has had three seizures and crushing headaches. House orders a scan but she explains that Stewart is an agoraphobe after he was shot and his girlfriend killed during a mugging seven years ago. Cameron met him as part of an outreach program, although House suggests she's trying to get back on the team. He notices Cuddy outside and goes to talk to her. She wants to talk about the night before when they kissed but he isn't interested. She thanks him for not taking advantage of her. Once back in the meeting, House boasts that he had sex with Cuddy so everyone figures he's joking. House suggests they provoke a seizure and locate the focus via EKG, then orders them to search Stewart'a apartment. Cameron takes the team to Stewart's house but he only lets one person come in to provoke a seizure while the others search the house for toxins. Cameron prepares to provoke a seizure and Stewart asks for a second. He recognizes her from the outreach program and when she tries to sympathize, he says he has everything he wants in the house and she doesn't know him. Wilson comes to see House and figures out he actually did have sex with Cuddy. House plans to ignore her and is busy itching a mosquito bite. Wilson wonders why House hid it from him but House interrupts to take a call from the team, who have found nothing and haven't set off a seizure. As he lances the mosquito bite, House is interested in discussing Cameron and Chase's love life and the fact they're not engaged and only meet at Chase's place. When House determines that Stewart seized in the hallway, he decides to bring the outside to Stewart. House arrives with some patients from the ER looking for a house, and finds that only Taub is there. House notes that he shouldn't be there and takes the patients in to inspect the bedroom. Stewart feels stomach pains but the readings show it isn't a seizure. The team runs a differential and finds a partial small bowel obstruction. They need to do exploratory surgery for a biopsy of Stewart's bowels but Stewart ordered them out. House warns Stewart that he has a blockage that could rupture his intestines but Stewart refuses to go outside. House compromises and suggests Chase come to the home to operate. Outside, Cameron objects and House explains they'll have Chase come to operate, administer anesthesia, and then they'll take him to the hospital. Cameron thinks it's immoral but eventually gives in. Chase arrives and as they begin the operation, Stewart says Cameron is a good person. As soon as Stewart is out, they take him to the hospital. Wilson meets with Cuddy in the cafeteria and she quickly admits she kissed House. She insists they're just friends and Wilson wonders why she doesn't get involved with House. Cuddy has given a lot of thought to the fact they'd eventually turn on each other and it would end badly. He notes that might not necessarily be bad. Cuddy says she'll be more careful and gets a pager beep. Cameron and Chase are bringing Stewart in and Cameron suggests they go to her place and he stay over. Chase is puzzled, but Cuddy catches them, aware that they took the surgical equipment. She brings them in and House is curiously passive as Cuddy notes it's setting them up for a lawsuit. House notes he doesn't care what happens as long as Stewart gets post-op. As they leave, Cuddy notes that House's hand is bleeding from the mosquito bite but he disregards it. Meanwhile, Cameron wakes up Stewart so he doesn't have a shock later. He panics and rips out the IV and starts bleeding from the neck. Chase returns and manages to get the bleeding stopped. Stewart calls his lawyer and forces them to release him, and the lawyer now holds the health care proxy and they still don't have a diagnosis. Cameron insists she made the right call but Cuddy takes them all off the case. Cameron wonders why House didn't object but he figures it's easier to ignore her and orders treatment for the blockage. Chase wonders why Cameron is pursuing the case when they've been taken off of it, and why she's trying to get involved with House's team again. She pointedly notes that she quit: Chase was fired. Cameron goes to Stewart's house and apologizes, then convinces him to let her in. meanwhile, Wilson talks to House and says that things are different between House and Cuddy now that they've kissed. Wilson figures House is scared but House wonders why Wilson is so worked up about it. Wilson suggests that House should date her but House figure Wilson is trying to live vicariously through him and wants to make House miserable because Wilson is miserable. Cameron reports the drugs aren't working and suggests they do the surgery at Stewart's home for real. They need a surgeon and Chase won't go near it, so House asks Taub to do it and they begin with Kutner assisting. They remove the bowel for biopsy and determine he has Whipple's Disease. As they prepare to cauterize a bleeder, they ignite gas buildup from the blockage. They put out the fire and put Stewart on antibiotics for the Whipple's. As Cameron goes over the case at Stewart's house, Chase brings her coffee and suggests he stay at her place. She says he can't because she's working on Stewart's case. Before they can pursue the matter, Cameron is called to Stewart's bedroom: he says his legs are numb. The paralysis eliminates Whipple's as a diagnosis and Foreman concludes he has Celiac and isn't absorbing nutrients. House tells them to force-feed Stewart wheat. The process is painful, and Cameron believes House ordered it to force Stewart to change his mind and come to the hospital. She says they can do a painless blood test but Foreman notes force-feeding is valid and they go ahead with both tests. Wilson visits Cuddy and admits he has feelings for her. She agrees and offers to have dinner, and then suggests they just have sex in front of House's office. She figures that Wilson is trying to make House jealous so he'll have a relationship with Cuddy. She thanks him for the attempts… and tells him he's an idiot. Cameron suggests that Stewart has post-traumatic stress disorder and he says he's had it ever since he's been a child. The only thing that led him to go outside was meeting his girlfriend Angela. House goes to see Taub as he runs the blood tests, and dumps out the blood. Taub figure House wants him to slow down the test and the increased pain will force Stewart to come to the hospital. He tells Taub to restock Stewart's morphine with saline. When Taub wonders why he'd do that, House says his wedding is on the rocks, which is why he's putting in the extra time. Taub says he's sleeping on the couch but will do it anyway. At home, House sets up a propane tank to emit gas and smoke out the mosquito. The mosquito lands and House tries to hit it, knocking the tubing loose. He chases it into the kitchen where it lands on the stove. He tries to hit it again and turns on the flames. The propane tank explodes… and House wakes up from his dream. He goes to see Wilson, who thinks that House is imagining things and he itches his hand when he thinks of Cuddy. He suggests that House is afraid to try a relationship but House insists he isn't rationalizing. He goes to visit Stewart for another check and Stewart's heart stops. House calls the lawyer to inform him they have a medical emergency and they need permission to take Stewart to the hospital. The lawyer agrees but Cameron revives Stewart and tells House to cancel the ambulance. Taub puts in a temporary pacemaker to stabilize Stewart's heartbeat but it's a temporary measure. House believes it's a poison and when the team says the house is clean, he asks Stewart how often he washes the tub, and if it's with bleach and ammonia. House figures the combination of chemicals make chlorine gas, and Stewart weight loss from stress is reducing the amount of fat to absorb the gas, causing his illness. Cameron goes to Chase to see if he'll put in a permanent pacemaker at Stewart's home, but he refuses. He knew she knew he'd say no and asks what's wrong between them. When she refuses to discuss it, he says that he has them stay at his house because he can tell she doesn't want him at her place. She kicks him out every morning and never offers him a drawer or closet space. He knows she's reluctant to get involved because of her husband but won't chase after her forever. Cameron calls House to inform him that Stewart's signs are dropping. He tells Cameron to call Taub to get some morphine there, but Cameron realized House switched the morphine for saline and gave Stewart morphine. When House realizes Stewart was having abdominal pain even on the morphine, he checks the blockage on the x-rays. He goes to Stewart's house and shows her the x-rays, which show a bone mass that is actually lead. House opens up Stewart and reveals several pieces of lead. The hollow point bullets the mugger used hollow-point bullets and fragments lodged in Stewart's hip bone. They finally started to dissolve, causing all the symptoms. Cameron wonders if the lead poisoning caused the agoraphobia, but Stewart insists that he's fine and doesn't need to change. Cameron wants his life to be better but House says that Stewart is lying and he's not happy. The rose petals in the hallway, Stewart dropped them as eh was preparing to go to his girlfriend's grave on her birthday. House tells Stewart to do something but don't believe his rationalizations. Cameron confronts Chase and admits he was right, and that her husband's memory is still affecting him. She tells him she's cleaned out a drawer for him. They go to her apartment. House is playing the guitar at home when he finally sees the mosquito. He prepares to smash it but then blows it away and decides to set aside his own rationalizations. He goes to Cuddy's house. Stewart braces himself… and steps out of his house. Taub's wife goes to him and they hug. House looks at Cuddy from outside. She doesn't notice him. He considers for a few moments, then turns and leaves.
Workers at a factory are discussing their relationship when their co-worker arrives: Sophia, a 16-year old. As she talks to the guy, Doug, Sophia clutches at her chest and falls onto the conveyer belt heading toward the press. They stop it just in time as she starts coughing up blood. House comes into work and Wilson concludes that he didn't ask Cuddy out. When Wilson doesn't comment, House suspects something is up. The team takes on the case and Kutner explains that Sophia is an emancipated minor working at the factory Foreman suggests Sophia is pregnant. Kutner doesn't believe it, or that she's taking drugs as Thirteen suggest. House orders Kutner and Foreman to do an echo and Foreman asks to be let go temporarily to do clinical trials. House refuses to let him, claiming that he might need him. Kutner gives the echo test to Sophia and tries to let her know that he understands. She isn't impressed but he notes that his parents died when he was six and he knows how she feels. Taub and Thirteen go over Sophia apartment and find a bong. Thirteen is skeptical of Kutner's trusting nature and Taub insists that some trust is necessary. Kutner suggests that Sophia needs steroids for vasculitis but House tells Foreman to put her on beta-blockers. Foreman tells the rest of the team to take care of it and leaves. Kutner administers the beta-blockers and Sophia claims the bong belonged to her ex. She admits they have no reason to trust her, and Kutner suggests she has vasculitis, but if she's using drugs the steroids could kill her. She insists she hasn't used drugs and Kutner goes to get the steroids. Foreman goes to the clinic and Cuddy arrives to ask why he's there. She's not interested in overriding House and wonders if he's trying to prove something. Foreman checks out a young kid, Jonah, who is suffering from bloody vomit and diarrhea. His older brother Evan is surprisingly knowledgeable about medical procedure and thoughtful of his brother. Meanwhile, Sophia has a psychotic break and they sedate her, and Kutner admits that he gave her steroids. The team stabilizes her and House blames Foreman for leaving it up to Kutner. Foreman suggests prinzmetal angina that caused an artery in the brain to spasm, and House reluctantly agrees, but orders Foreman to trigger an artery spasm. Foreman tells the team to set it up and page him when they're ready to actually run the procedure. He returns to check on Jonah and has him swallow a camera. Evan convinces him to do it and Foreman notes that he didn't treat his younger brother that nicely. Jonah starts giggling uncontrollably and Foreman has no idea why. He talks to Cameron and Chase and asks for a differential but Chase isn't interested. He informs them it isn't House's case and they decide to look at it, but Chase warns it won't be enough to prove anything. Foreman is called away as Kutner begins the procedure and talks about her parents being dead. Sophia's arteries are fine but he's able to tell from the blood flow that she's lying. Kutner is angry at her but she says she told the truth about not using drugs but lied about her parents because her father raped her and her mother didn't do anything about it. Back in differential, House notes that the rape has nothing to do with the symptoms and therefore isn't of interest to them. Kutner suggests she might by lying about the rape and House notes that she might be suffering from emotional stress, explaining the symptoms. House orders them to give her anti-anxiety drugs and to make sure Foreman did it. House talks with Wilson and explains what happened but Wilson isn't interested in giving opinions or insights. House is less than thrilled. Meanwhile, Chase and Cameron give a differential to Foreman but can't come up with anything major, while Cameron notes that Foreman needs to focus on one case or the other. He ropes them into testing Jonah and goes to see Sophia where Thirteen is giving her the treatment. She apologizes and Thirteen suggests she file a police report on the rape. Sophia refuses, saying she doesn't want to be labeled. However, Foreman realizes the drugs aren't helping: her urine has turned brown. Back in differential, they wonder if the shredded red cells indicate an infection, but it doesn't correspond with her previous symptoms. House wonders about Sophia's homemade furniture and Thirteen says that there were holes, indicating they were pressure treated. Sawing the lumber would have released arson into the air, and Foreman suggests they test her hair as it wouldn't show in a bloodtest. He gets a page and leaves, raising House's suspicions. Foreman meets with Chase and Cameron, who reveal they haven't found anything. Chase says that he needs more help then they can provide but Foreman doesn't think they're at that point yet. Jonah goes into cardiac arrest and they're forced to revive him. Chase tells him they're at the point. Thirteen removes the arsenic from Sophia's body with chelation and says she's free to go in the morning. Sophia wonders why she doesn't give her any advice. She finally gives in and asks Thirteen for her opinion, and Thirteen says that she's strong and can handle things. Sophia has a seizure and House concludes that the arsenic was fighting what is killing Sophia and tells them to put it back in. They figure it's acute leukemia but arsenic won't cure it: she needs a bone marrow donor. Foreman comes in and House knows about Jonah. Foreman said that Jonah needs House but House isn't interested. He tells Foreman that he wanted the case for himself, so now he has it. House confronts Wilson and figures that he's not doing anything to force House to deal with it. Wilson simply shrugs and agrees and goes on his way. As they conduct a biopsy, Thirteen tells Sophia that the odds of her finding a suitable donor are better if she goes to her parents. Sophia would prefer to die then involve them in her life. Taub lies and says he has Huntington's, and says he'd do anything to stop it so he can make his life matter. Sophia asks if he's been raped and when he says no, she tells him he can't understand what she's going through. Thirteen is angry that Taub lied to Sophia using her disease, and Taub points out Thirteen never relates to Sophia personally. Thirteen angrily insists that they contact her parents even though Sophia doesn't want to, but House refuses. She says she plans to find Sophia's parents. Cameron and Chase meet with Foreman and Foreman points out that Foreman has got what he wished for. Chase wonders if the mother or brother are involved. Foreman notes Jonah shares everything with his brother and gets an idea. Thirteen goes to talk to Sophia's parents to test their suitability as bone marrow donors only to discover that their daughter Sophia is living with them… and it's a totally different girl. Thirteen confronts Sophia, saying she stole Sophia's identity. Sophia admits she did it to protect herself from her real parents and asks Thirteen to pretend she didn't find the girl. Thirteen tells her to call the parents so they determine their donor suitability, but Sophia refuses and notes that when she gets sick enough, they'll have to give her the transplant without parental consent. Foreman has realized Jonah is suffering from an iron overdose: Evan gave his vitamins to Jonah. Evan is sorry but Foreman assures him that Jonah will get better and forgive him. House arrives at work the next morning and the team has a partial match, but a partial could make it impossible for Sophia to receive a second donation if the first one fails. House tells them to treat Sophia no matter what. They note that she was rational first rather than emotional and House notes that it's unusual and wonders if she lied because something worse happened then rape. He goes to see Sophia and asks her what happened. He asks why she doesn't want pity and she insists she wants to be normal. He realizes she did something that makes her not want to live and asks what she did. Sophia refuses to answer, saying her parents won't care. When House snaps at her, she finally admits she killed her brother: he drowned in the bath when she was watching him. House tells her that if she dies by refusing treatment her parents will hate her for sure and there's one thing she can do to keep it from getting worse. Sophia's parents come in to help her. Jonah and Evan leave with their mother, who hugs Foreman as she leaves. Kutner looks on as Sophia is reunited with her parents and breaks down crying. Foreman confronts House and says he's going to do clinical trials, having proven he can handle two cases. House easily gives in and Foreman wonders why: House notes that before Foreman asked him, and this time he told House he was going to do it. As House gets in the elevator, Wilson gets in and finally says it was a nice thing he did for Foreman. Wilson explains that House needed to prove to Foreman he could handle it, but House points out it doesn't work the same for him. They see Cuddy as they're going out and House isn't interested in talking about her. Wilson says that he'll be okay.
At the clinic, a variety of patients are waiting for treatment. One man, Larry, wants migraine treatment but Thirteen tells him it's not an emergency and he can wait. Foreman approaches her and asks if she wants to participate in his drug tests for potential Huntington's cures. She tells him she isn't interested and admits she isn't doing anything to treat it. One man, Jason, notices Cuddy's office and sees House inside. He goes in to ask for Dr. Cuddy. House is going through Cuddy's desk and tells him to leave. Jason goes out and takes out a gun. A minute later, House looks up as Jason ushers Thirteen, one nurse, and several patients into the office. Jason demands the best doctor in the hospital or he's going to start killing people. Jason forces his hostages to barricade the room and draw the blinds. House refuses to back down and notes that taking hostages is unlikely to go well. Jason has his medical files and says he can't breathe, he's tired, he gets skin rashes, palpitations, and insomnia. House wonders if Jason is having marital problems but Jason says he's never been married. House then tries to borrow a match to administer a breath test. House warns Thirteen not to go through Cuddy's desk and one kid, Oliver, provides a lighter. Jason is unable to blow it out held at arm's length. House concludes he has pulmonary scleroderma, and an alkylating agent will solve it. House calls out to ask for propofol to test for scleroderma and Jason demands that Cuddy bring it in, recognizing her from her photo. Cuddy brings in the syringe but Jason tells him to give it someone else. House notes that everyone else is ill but Jason notes that Larry isn't on pain-killers. Larry suggests Jason give the first dose to Thirteen and House notes she's sick. House gives the injection to Larry and nothing happens. However, when House goes to give it to Jason, Larry passes out despite his larger body mass. Jason prepares to shoot House but House warns that Jason needs him. Jason shoots another patient, Mitch, in the leg instead. Lt. Bowman of Princeton SWAT arrives and takes command. Cameron, Chase, and House's team are working with the patients when House calls them for a differential. He relates Jason's symptoms but a disgusted Chase refuses to participate and walks out. The team comes up with various possibilities but they need to test. House has Foreman and Cameron run tests while Taub and Kutner check Jason's apartment for neurotoxins. When Jason gives out his address, House realizes that Jason has an escape plan. House calls and talks to Bowman to get someone to pick up Jason's blood samples. Jason notices someone outside by the blinds and orders everyone back when he sees SWAT officers outside. House notices that only Jason heard the men, indicating hyperacusus, which indicates nerve damage. He has Jason puff out his cheeks demonstrating left-side nerve weakness, indicating post-herpetic neuralgia. There's a dangerous and painful test that only hurts if the diagnosis is wrong but Jason demands proof and agrees to it. Bowman gets two hostages in return for the medication but is reluctant to send Cuddy in. Cuddy instantly agrees and Bowman wonders if she has a stake in it. Cuddy insists she's okay. A teenager, Oliver, volunteers to take the shot even though it could cause muscle and nerve damage. House does a quick test and the husband of a pregnant woman, Bill, ends up last. He refuses to take the shot and Thirteen volunteers. House isn't thrilled, noting it's her Huntington's speaking, but she insists and collapses in pain. House then gives Jason the shot while wondering why he's so desperate to find a cure that he takes hostages. Jason suffers the same pain, indicating he doesn't have neuralgia. Taub and Kutner check Jason's house and Kutner finds a photo of Jason with his mother. Foreman tests and determines there's no blood infection. They're left with a heart condition or cancer. Kutner notes that the photo of Jason's mother suggests either an upper-lobe tumor or adrenal problem. Thirteen notices that Jason has a distended jugular, indicating a heart problem. Jason's pulse is racing and Thirteen says they need paddles. House prepares to do a carotid massage but Jason refuse to let House gets that close, since the paddles will cause his trigger finger to spasm. Thirteen suggests they cardiovert chemically and goes to get the drugs, and House notes Jason can shoot someone else if Thirteen doesn't come back. Jason grabs Oliver and gives Thirteen 30 seconds. House and the hospital nurse, Regina, wonder if Thirteen will come back. Time runs out and Jason prepares to shoot Oliver, but Regina volunteers. He prepares to shoot her and she says Jason needs more time. Thirteen comes just in time but Jason insists that Thirteen take the first dose. House warns it will stop her heart to lethal levels but Thirteen gives herself the injection and collapses. Jason takes the show and House notices he's only sweating on one side of his face: a tumor is pressing on his sympathetic nerves. House concludes he has lung cancer. House calls Wilson for a consult and they check his throat. Jason displays dry throat, indicating cancer, but he insists on a CRT scan. Jason releases two more hostages in return for a trip to Radiology, then ties Bill, Oliver, Regina, House, and Thirteen around himself and edges to the elevator. Housie still wants to know what drove Jason to get a gun and suggests it was the humiliation of being poked and prodded by doctors. Jason insists that he simply wants an answer. They get to Radiology and House runs the scan, while insisting there has to be a deeper reason than curiosity. Jason insists it's his life and his body, and there's a truth he'd rather know even if he has to rot in jail. House stops the scan and writes down the problem, then has Thirteen explain to prove they both know the problem and didn't pre-plan things. The scan has a starburst artifact: the metal is messing up the scan. House tells him he'll have to give up the gun to get is scan. Jason threatens him with the gun, and Nurse Regina and Bill run out, explaining that Jason gave up the gun. House runs the scan and ignores the phone, while Oliver watches. He admits he's curious and it should be safe now. House goes over the scan, ignoring Cuddy and Bowman's attempts to call him, and he's forced to reveal there's no tumor. Jason thanks him but House, curious himself, gives the gun back to Jason to maintain the situation and get the answer. House finally answers the phone and tells them Jason got the gun back. Thirteen accuses House of being a coward for refusing to accept he can't find the answer, but he accuses her of being a coward for giving up on living. Oliver wants to go but House says they might need him. Outside, Bowman wonders if House is lying but Cuddy disagrees. Bowman starts to set things up for an assault. House calls the team again and Foreman walks off, realizing Chase was right. The team toss out possibilities and House notices that Jason is now losing hearing in his right ear. Cushing's Syndrome accounts for all the symptoms, even the risk-taking. House calls Cuddy requesting a drug to provoke a respiratory reaction to confirm Cushing's. Bowman refuses to negotiate but Jason releases Oliver and agrees not to test the drugs on Thirteen. Oliver gets out and Cuddy delivers the drugs over. Jason tells House to give it to Thirteen, and admits that he lied to Bowman. He believes that Bowman might have slipped in fake drugs even if House wouldn't. Thirteen injects herself before House can object. Jason asks her how long she has to live and she admits there is no cure. Convinced, Jason takes the injection and admits that at least there was an upside to his risks: she isn't gaining anything. Jason's breathing doesn't change but Thirteen collapses as her kidneys shut down. House calls his team and Cameron suggests that the various medications Jason has received may be protecting his kidneys. House slaps Jason and spots a twitch, indicating a calcium deficiency. Drugs that cause calcium deficiency also protect the kidneys. House tries to add up all the symptoms and Cameron suggests it's meliodosis. The disease requires exposure in a tropical environmental and the history doesn't indicate that… until Jason admits he's been to Florida. House has the disease but Bowman refuses to give them the cure. Jason offers to release House as a hostage and House realizes Jason plans to give the drug to Thirteen. House volunteers but Jason points out that Thirteen is the one on the same drugs he's been taking. Thirteen tells House to go: either way she'll die. House walks outside while Thirteen wonders if Jason will feel bad about killing him. He says that she wants to kill herself but needs someone else to do it for her. The SWAT teams move in and plant a frame charge on the wall. Thirteen tries to inject herself but hesitates, saying he has to trust people. Jason prepares to shoot her and Thirteen tries to inject herself… and stops, saying she doesn't want to die. Jason grabs the syringe and injects himself, and the SWAT team blasts themselves in, knocking Jason and Thirteen to the floor. The police haul Jason away and House wonders why Thirteen is still alive. She explains that Jason spared her, and outside Jason and House exchange a look of understanding. Thirteen begins a one-week regimen of temporary dialysis and Foreman apologizes for leaving the diagnosis. She asks if she can participate in the drug trial. Cuddy surveys her devastated office when House comes in. He explains the test confirmed meliodosis and she snaps at him, wondering if that's all he cares about. He points out that Jason would have been dead if they hadn't, and she helped him. She wonders if she screwed up because of their non-relationship, and he notes that the only change would be to have a relationship. She wonders if he wants a relationship and he denies it, saying he was just trying to follow her logic. As he leaves, she pulls out the desk drawer and it breaks off: House's prank from earlier finally goes off.
Fitness guru Emmy is filming a commercial at a stadium while her overweight clients exercise behind her. One of them collapses and Emmy helps him up and tells the other s to keep running. She insists on exercising with them so it looks real. She runs with the man up to the top… and then collapse, falling down and breaking her ankle. Cuddy catches House in the elevator and gives him the case, and informs him that she'll be sharing his office since the recent hostage situation destroyed it. House meets with Kutner and Taub, since Foreman and Thirteen are in the clinical trials. Kutner is familiar with Emmy and suggests allergies. Cuddy, in the office, points out the flaw in that differential and suggests that cold air and exercise is setting off asthma. House notes that there's no high blood pressure and gets Taub and Kutner out… and tells them to check Emmy for asthma by recreating the conditions of how the attack occurred. As Thirteen waits for the clinical tries in the waiting room, she sees a female patient with advanced Huntington's, and remembers her mother having the disease when she was a child. Taub and Kutner take Emmy to the refrigerated morgue and have her exercise. She insists on exercising and Taub wonders if she ever indulges. She says she never does… and then collapses. Foreman conducts tap testing on Thirteen, who insists on talking about how she shouldn't be there when there are others. Foreman insists she's just there because she has Huntington, and tests again after telling her not to talk. She keeps talking and he finally confirms that she's suffering nerve degeneration. Cuddy is playing with House's ball, irritating him, and he says they should split the desk. She readily agrees and he warns her that being nice won't work. Taub and Kutner report about Emmy's new condition and that her heart stopped. Asthma isn't responsible for her symptoms. Kutner suggests a carcinoid tumor strangling her system and House tells them to find it and cut it out. As Kutner and Taub scan Emmy, Kutner asks for Taub's input on a leaking breast implant that might cause join pains. Kutner explains that he's set up a web site that provides medical advice and second opinions. Taub wonders if Kutner wouldn't mind if he told House, and Kutner admits he set it up in House's name. Taub threatens to tell House unless he gets a 30% cut. They're interrupted when they discover that Emmy has a shrunken stomach: she's had stomach stapling. House finds an old photo of Emmy showing she was fat, and then had the photos pulled from her records. Their conversation interrupts Cuddy, who is on the phone. House tells them to treat her like a fat girl and Kutner wonders if she had Type 2 diabetes. House tries to embarrass Cuddy on the phone but she refuses to flinch and takes the call outside. Kutner suggest sleep apnea that cut off the trachea and House insists it isn't apnea. He goes to where Foreman is conducting private tests with Thirteen. Thirteen is seemingly eager for the distraction and suggests side effects from the gastric bypass, leading to low potassium. House notes her potassium is fine but Kutner suggest that the bypass could have created a closed loop of intestines that caused bacteria, leading to sepo. House tells him to check her feces. Foreman points out they could have done the diagnosis anywhere but House says that it helped. Taub explains the procedure and notes that Emmy is a hypocrite for not using the procedures she sells to her clients. She defends herself, saying she doesn't tell them to get surgery and she tried everything else she could but only gastric bypass surgery worked, and then she was happy. Taub wonders if she really is healthy and says that if she is, it's because she's pretty. Wilson talks to Cuddy who defends her decision to share Cuddy's office. However, he accuses her of taking House's office just to be close to House. She orders him out. As Kutner and Taub test Emmy's feces, Kutner says that Deedee, the person with the breast implants, is going to complain to the licensing board if he doesn't come up with an answer. House comes in, just missing the conversation, and tosses the sample in water to see if it floats. The lack of flotation means no sepo and the possibility of apnea. He tells them to watch Emmy overnight. As Kutner and Taub argue, they miss her getting up and going to the exercise room. She's running on a treadmill and says she feels great. She doesn't feel any pain from her broken ankle, or notice the bleeding. Taub pricks her with a syringe and she doesn't feel that either. It's back to differential as Kutner and Taub confirm that the EEG eliminates the apnea diagnosis. They return to House's office only to discover that Cuddy has "accidentally" spilled hydrogen sulfide, stinking up the place. She leaves for the night and wishes them well as they have to stay there all night to deal with the patient. They move to the hallway but Foreman is called away. Thirteen tells him to wait and he notes she missed the last session. She says she'll be along, then suggest MS. House notes there are any number of possibilities involving her nerves and they need to run a NCV test to determine where the problem is. Taub administers the NCV test and says he isn't interested in Emmy's rationalizations. She admits that if she was honest about the bypass surgery, no one would believe her but she wants to help people. She asks if he's done anything hypocritical and when she sees that her comment scores, says that he probably had good reasons too. She tries to lift her arm but is unable to do so, meaning the problem is with her muscles, not her nerves, and the NCV test is unnecessary. Foreman goes to the waiting room but Thirteen isn't there. Kutner and Taub are in the elevator discussing the case while a woman with tattoos and piercing stands behind them. She tells them she's going to see House and she's been e-mailing with him about her breast implants. Now she's losing her hair. They quickly close the elevator doors before House sees her and get her to the ER. Taub figures she has a staph infection from the piercings and tattoos. They go back to see House, who wonders why they took so long. Kutner suggests that House give up the office but he goes in and smashes Cuddy's new toilet. He then suggests chelation treatment for whatever toxins Emmy may have. Thirteen arrives home to find Foreman waiting for her. He admits that she thought she was becoming self-destructive again, but only confirmed that she's been following all of his instructions. He asks why she can't show up for appointments and she says that she came down but there was another patient, Janice, in the waiting room. She doesn't want a visual reminder of what she'll eventually be going through. Foreman tells her either to show up or not to show up at all. As he goes, Thirteen remembers back to when she was a child when her father said her mother was leaving but Thirteen refused to leave her room. The team meets on the stairs for a new differential once the chelation doesn't work. When Taub wonders why they're not meeting in House's office, he notes that Cuddy responded to his action by taking out all of the furniture. He's also interested that Thirteen is leaning away from Foreman. Foreman insists everything is fine and suggests Austrian's syndrome from alcoholism. House notes that Emmy doesn't drink and the tox screen didn't show alcohol anyway. First Kutner and then Taub get a page and both claim the call isn't important. Taub suggests Guillain-Barre, which leads from muscle weakness to total paralysis. House orders plasmapheresis treatment. Taub and Kutner finally respond to their page and discover that Deedee is uncontrollably singing. Cameron tells them to bring in House because she must have a rare brain disorder. When she notes that Deedee is bleeding from the ears, she tells them to get House. Taub explains to Emmy that she has Guillain-Barre and refuses to let her take a wheelchair when she's still strong enough to walk. Kutner meets with Cameron and Chase in the cafeteria and tries to get some input. He finally comes up with a bilary tumor causing pareneoplasic syndrome and Chase agrees. He also agrees to test for it… as long as Kutner pays him 25% of his website earnings. House is planning out his strategy to get back at Cuddy by replacing her toilet with a bidet. Wilson points out that the renovations will take longer, meaning Cuddy will be in House's office longer. He tells House to just ask Cuddy out. Emmy starts hallucinating, believing her patients have come to visit and sit on her now that they know she's lying to them. House goes to his office, now empty of furniture, for a new differential given the new symptoms. Thirteen leaves for her appointment, suggesting it's CNS lymphoma. Taub suggests a prion disease but House notes if that's the case there's not much they can do. House orders a brain biopsy but Cuddy overrides him, suggesting they test for CNS lymphoma non-invasively first. He orders Kutner and Taub to run the non-invasive tests and then confronts her, saying she's overriding him because she has the hots for him. She accuses him of having the hots for him. She says that they're supposed to kiss now, but he points out they've already done that. Instead he grabs her breast. She admits she's an idiot for being surprised and walks off. Thirteen arrives at the waiting room and sees Janice. Foreman says he can't reschedule and Thirteen might as well get to know her. As Thirteen looks at Janice, she remembers being in her bedroom as a child and watching her father take away her father. She then goes over and meets with Janice. Taub has eliminated CNS lymphoma and Emmy asks to stop by the cafeteria for chocolate cake. He tells her not to give up and she wonders what they're hoping for. He admits that prion disease is next on the list and that it's bad. She says she might as well have a piece of cake and he agrees. Later, Taub goes to House's office and tells him that Emmy tested negative for CNS lymphoma. He notices that the furniture has been returned. House asks Taub about his affair and if he was happy during it. Taub admits that superficially he was but deep down he was miserable. House notes he wasn't miserable, because he rationalized getting something for giving something. Taub, bemused, goes to get Cuddy's permission for the brain biopsy. House interrupts him, saying he'll do it himself. They go to Emmy's room and find her exercising. With the new "symptom," it's back to differential and House doesn't believe someone could get better. Taub says the last thing he did was administer a MRI and then they went to the cafeteria for chocolate cake. House notes he's an idiot and takes a chocolate cake to Emmy. She's feeling worse again and serves her a piece of cake. House explains that she has hereditary coproporphyria which causes a lack of a vital enzyme to the liver. The treatment is a high-carb diet and sugar. Once they reverse the bypass surgery and she fattens up, she'll be fine. Emmy wonders if there's anything else they can try and Taub says there's a drug that manages the symptoms. She agrees to the drugs and refuses the surgery. House understands that she's rather be pretty than healthy. Taub admits to Kutner that he's disappointed that Emmy is just as superficial as most other people. They go to see Deedee and a nurse informs them that she died and was moved before they could be reached. Cuddy returns to her newly renovated office with Wilson, talking about how House isn't capable of intimacy. She sees her desk and realizes it's not the desk she ordered, but her desk from med school that she had in storage. She thinks about it and realizes who put it in there. Thirteen admits to Foreman that she lied to him: Janice reminds Thirteen of her past, not her present. She admits that she wanted her mother to die after she lost her facilities in the last stages of Huntington's and yelled constantly at her. She never said goodbye to her mother, who died with Thirteen hating her. Foreman hugs her. Kutner and Taub go to the morgue and Kutner berates himself for not taking more time. House arrives and says he's going to kill them, accusing them of being frauds and idiots who got a woman killed. He says that Deedee could have been treated and then wonders if it's not too late. He climbs up on her and applies CPR, and she comes back to life. Kutner and Taub jump back in terror… and House and Deedee burst out laughing. House set the whole thing up, and hired Deedee for two days to pretend she was the client. Kutner offers to take the website down, but House says to keep it up in return for 50% of the profits. As they go to work, Deedee points out that House still has three hours left. Cuddy goes to House's office to thank him… and see him with Deedee. She turns around and leaves.
At a school academy Christmas pageant, a group of older students are planning to embarrass the teacher over the reluctance of one girl, Natalie. Thy go out on stage and start singing, and Natalie starts to get dizzy. She sings out the teacher's name when the others stop, and then she collapses, vomiting. Natalie goes to the clinic where Cuddy turns the case over to House and his team, saying that Natalie's liver is failing. House notes Foreman's vacation and that Cuddy keeps coming to him. She says it isn't and walks out. As they return to the case, Taub find a Christmas present for House but House angrily throws it away even though it's a valuable antique medical text. He wonders if the other students pranked Natalie and slipped her something. Chase and Kutner talk to the students and they eventually admit they slipped her some mushrooms. The boy who supplied them, Simon, didn't think they were dangerous but Chase notes that they can be if not prepared properly. Foreman is checking up on Thirteen, who asks him what happened with his patient Janice. He says she dropped out of the trials but didn't say why. He tells Thirteen that she's improving and as she goes, she leaves him a thank-you present for Christmas. Kutner and Taub got the school to get the mushrooms and discuss what House is up to, and figure it's legitimate. They go through Natalie's locker and find a bottle of painkillers. Cuddy asks Natalie why she was taking so many painkillers. Cuddy admits she doesn't have any kids and Natalie says she's overweight and the other kids hate her. Cuddy tells her to forget them and then talks to their parents, who insist Natalie didn't take the pills. However, Mrs. Soellner admits that Natalie has changed in the last year and finally agrees to have Cuddy give them the treatment for an overdose of the painkillers. Kutner and Taub go to Wilson and describe the present, and he recognizes it. He admits it came from Irene Adler, a patient in 2001, who House saved after a desperate effort… then admits he's lying to them and he recognizes that it's a present that he gave to House a year ago. They're called away when Natalie's heart problems and high blood pressure. Cuddy goes over the case with House and he points it out, but Taub admits they called her in because Foreman is busy. They go back to differential but Taub goes along with House's gag and suggests that Cuddy gave him the present, and he thinks she loves him. House refuses to discuss it but Taub plays along and tells House to tell Cuddy he loves her. House quickly figures out they're on to him, remembers that Natalie volunteers at a homeless shelter and orders Taub to do an anal swabbing at the shelter. House confronts Wilson, who wonders why House didn't open his present. He also wonders why House gave himself an imaginary present and figures the holidays are hard for House because he can't have a meaningful relationship. House thinks Wilson is trying to goad him into being nice to his patients, but Wilson says he isn't and even if it was he wouldn't worry. House admits he needs to stop being a jerk… and steals Wilson's ice cream. Thirteen goes to see Janice and asks if she can help. Janice says that she told Foreman the injections were making her ill and he told her to get over it. She refuses to be Foreman's guinea pig. Taub meets with House and tells him a worker at the soup kitchen had tuberculosis and the symptoms match with what Natalie has. House orders standard treatment and then goes into the clinic for duty. He starts acting sympathetically with the first patient, Whitney, and realizes she's pregnant. Whitney wasn't aware she was pregnant and House quickly loses his patience when she claims she's a virgin. As Natalie undergoes treatment, she starts to spasm due to brain problems and Cuddy concludes it isn't TB. House is back to differential and Cuddy is there again, and he wonders why. Cuddy says she cares for Natalie and House wonders if she does so because of the baby she lost. Kutner suggests a mold allergy to the mushrooms and House orders a prick test and anti-fungals. Thirteen talks to Foreman about Janice and brings up the nausea. She suggests Foreman apologize but when he refuses, she accuses him of acting like House. When Foreman stands by his decision, she says he is House. Whitney arrives with her fiancé Geoff and Whitney insists she didn't have sex. Geoff demands a paternity test and Whitney agrees to it. Meanwhile, Kutner and Taub give Natalie her test and suggests she talk with them. She says she's okay and works on her homework, noting that Simon brought it. Kutner calls security to hold Simon and demands to know what he did. Taub pulls him off and suggests Kutner is projecting his personal issues from being bullied in high school. Simon says that they used to be friends but he stopped when people made fun of him. He says that Natalie used to drink a lot ad he bought her alcohol with a fake ID until Natalie got her own. Cuddy confronts Natalie and warns that they can't get her on the transplant list if she's alcoholic. Natalie says she hasn't drunk in six months and bought the bottles without opening them, so she could still talk with Simon. Cuddy wonders why she stopped buying alcohol and Natalie doesn't have an answer. Cuddy explains that she initially didn't want children because of her screwed up relationships, but she changed as she got older. House meets with Anna, a woman with asthma, and tries to be nice again. Anna demonstrates how she uses her inhaler… by spraying it on the outside of her neck. Anna storms out a moment later and Cuddy arrives to explain she thinks Natalie either wants to die or the attention that comes with it. He proscribes benzos for the seizures which just happens to be the same treatment for alcoholism. House then goes to see Whitney and Geoff and sees something shocking in the paternity test. He tells them to stay and walks out. Foreman asks his partner, Dr. Schmidt, about whether he should pursue the case with Janice. She notes that they can't view the patients as people, only numbers. Foreman explains that a friend of his has the disease and she says she doesn't want to know: they can't afford to care and the test is a double-blind. He's not sure if he can be that detached but Schmidt says that's why she chose him: because he worked for House and she figured Foreman understood that. Natalie flat lines when her heart stops and Taub revives her. Meanwhile, House returns to Jeff and Whitney and says that she didn't cheat on Jeff. The baby only has Whitney's DNA: parthenogenesis in Whitney caused by a calcium spike lead to her pregnancy, even though there's never been a documented case. In seven months she'll have a miracle birth. Back in differential, House starts to explain about Whitney but Cuddy tells her they need to put Natalie on a pacemaker. Alcoholism would cause a heart rate increase. There's a high alk phos rating, suggesting leukemia, and they take it to Wilson who confirms it's possible. House orders testing and Cuddy wonders why he doesn't want to treat her. House wonders why she's so concerned and leaves it up to her. Wilson warns that there's nothing they can do and even a double transplant won't save her. Cuddy orders the biopsy. Foreman goes to visit Janice and says he can put her in a separate trial with a drug that won't cause nausea. He gives her the forms and leaves. An increasingly panicked Cuddy goes to see House and wonders if they've overlooking something. He points out that patients die every day and she can't afford to get worked up about all them. As he goes through his desk he finds a present from Whitney. He tells Cuddy about the supposed parthenogenesis and she notes the testing machine was down. House explains he faked the whole thing and then tosses his present to Wilson and says he won by proving he was nice to a patient and she thanked him. Cuddy is surprised but Wilson admits he was trying to be nice. Cuddy realizes that the seizures and liver failure indicate eclampsia, meaning Natalie was pregnant and her fetus is dead. Cuddy explains to Natalie and her parents that she has eclampsia, and you can get it up to a month after giving birth. Natalie quit drinking when she discovered she was pregnant, and concealed it. Natalie admits Simon is the father and he doesn't know about it. She was worried the other students would find out, but when it stopped breathing she left it at a house near the soup kitchen. Cuddy admits the damage to the heart and liver are permanent and there's nothing they can do. Natalie admits she just put her coat over the baby and left her. Cuddy goes to the abandoned apartment where Natalie left her dead baby. She finds a squatter living there and he tells her to leave. A woman comes in holding a baby and Cuddy realizes the woman isn't the mother. Cuddy wants to get the baby for treatment and says the woman has to let her go. Cuddy returns to the hospital and brings the baby to Natalie. Natalie holds her child and Simon arrives, and Kutner tells him to go in. Kutner goes to the hospital Christmas party, clearly upset, and tells the others about what happened and that Natalie only has a couple of days left. The daughter is being kept for observation and could end up with Simon. Kutner then goes to see a man, Jonathan, and apologizes for bullying him in high school. House visits Cuddy as she watches over the baby. She explains that the grandparents are putting the baby up for adoption, and she'll adopt it. House wishes her a Merry Christmas and leaves. Thirteen visits Foreman and admits she was wrong and he's not House. Foreman says he got Janice on the trials as a Christmas gift to her, and proved he wasn't House as a gift for himself. She suggests they go to the party but they embrace and kiss.
House and his team deal with a man living in constant pain. Meanwhile, Thirteen receives treatment by Foreman while taking part in his clinical trial on Huntington's Disease, and Cuddy tries to balance her hospital duties with her new baby.
The team take on the case of a Special Education teacher who spits up blood and collapses in the middle of class. Meanwhile, Cameron finds herself taking on some of Cuddy's duties, including dealing with House, and Foreman has to make a decision concerning Thirteen's participation in the clinical trials.
A former cancer researcher collapses in the middle of a cooking class, and the team is forced to reevaluate their own lives when they learn she gave up a promising career to seek personal happiness. Meanwhile, Thirteen suffers adverse reactions from the clinical trials, and Cuddy gives House a dose of his own medicine.
House struggles with his own beliefs as he takes on a case of priest with a disturbing past who runs a shelter for homeless people and sees a vision of Jesus.
A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.
House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe disinhibition, which causes him to speak his mind having no control over what he says and making him just like House. Meanwhile, House suspects Wilson and Taub are keeping something from him.
A nursing home worker, Morgan, fakes an illness to get House to examine a cat which can predict the death of elderly patients. House doesn't believe it... until Morgan becomes ill for real.
House is injured in a motorcycle accident in New York and finds himself in bed next to a patient suffering from complete paralysis. As House transfers the patient to Princeton to determine what's wrong with him, Wilson tries to find out why House was in New York.
The team deals with an older woman who has been tending to her dying husband but is stricken down with an unknown disease that threatens to kill her before her husband. However, they must overcome their own emotions when a tragedy strikes one of their members.
Cameron postpones her vacation with Chase to take on the case of an environmentalist who collapsed in the middle of a protest. Meanwhile, House wonders why Wilson is starting a new healthy diet.
A deaf 14-year old wrestler suffers from hearing problems during a match, but his mother refuses to okay cochlear implants. Meanwhile, House's insomnia proves a curse... and a blessing.
While House tries to cope with his insomnia, he takes on the case of a ballerina whose skin begins to fall off after treatment following the collapse of her lungs during a performance.
House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his actions. As the two sides of Scott's brain struggle for dominance, his warring personalities make it increasingly difficult for the team to figure out what is causing the unique problem. The team is forced to use some unusual methods to get him to cooperate with their necessary testing. Meanwhile, when House refuses to make an appearance in the clinic, Cuddy takes an unconventional approach to force House to make up the time with a particular patient (guest star Reiner).
House engages in a battle of wits and wills against the attending physician in charge of his detox program. When he starts to lose, House resorts to blackmail to gain the upper hand.
House returns to Princeton Plainsboro, announcing he will make big changes in his life. Meanwhile, House's team can't diagnose a new patient who's obsessed with posting each and every one of his symptoms over the Internet.
House's team struggles with an African politician who falls ill and decide if they want to help him after he's charged for crimes against humanity in his country.
A rich businessman brings his son, who's suffering from stomach pain, to Princeton Plainsboro, and believes he's a victim of his wealthy position and success.
A dying patient insists that he has the same disease affecting his heart that killed his father and grandfather at the age of 40. Meanwhile, House discovers that he has a hearing problem while trying to duck student rounds.
House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.
House is finally reinstated and takes on the case of a porn star with eye pain. Meanwhile, Chase and Cameron try to resolve their relationship issues after Chase's admission, and House tries to bring back Taub and Thirteen.
It's Thanksgiving, and the team discover they have little to be thankful for in their personal lives. Meanwhile, House takes on the illness of a brilliant physicist who has rejected his intellect to work as a courier.
Wilson insists on treating the case of a friend and former patient, Tucker, who is suffering from paralysis of his right arm. However, he soon discovers that he can't separate his feelings from his professional attitude. Meanwhile, Cuddy tries to buy a new house.
A drug dealer collapses during a sale, but refuses to reveal personal information to the team because it might incriminate him. Meanwhile, Foreman's teammates conspire to play a practical joke on him, while House and Wilson both aim their sights on an attractive new neighbor, Nora.
House decides to take on the case of a beautiful female executive based on her looks, and the other males on the team are equally smitten. Only Thirteen is able to remain unaffected as they try to determine the cause of the woman's illness. Meanwhile, House tries to resolve his past with a former medical school colleague he wronged.
The team disagree on how to treat a college football player who wants to be cured in time to complete in the NFL tryouts. Meanwhile, Foreman's brother Marcus pays him a visit.
It's a day in the life of Cuddy when she has to deal with her personal and professional life, insurance contract negotiations, a thieving pharmaceutical technician, an ailing daughter, and House and his team.
The team tries to diagnose a famous blogger who insists on publishing her life on the Internet, much to the regret of her partner. Meanwhile, House and Wilson each discover secrets about each other, and Chase goes speed dating and discovers something about himself.
House and team tries to diagnose a high school senior suffering from blackouts and hallucinations, and are forced to take a controversial approach. Meanwhile, Wilson attempts to furnish his new condo, and Taub brings his personal life into the workplace.
Princeton Plainsboro goes on lockdown after a newborn disappears from the nursery. House is trapped with an inquisitive patient, Foreman and Taub are sealed in the records room, Wilson and Thirteen play Truth or Dare, and Chase is locked in with a familiar face.
Sir William, who dwells in a isolated community of people living in a medieval style, is stricken ill and the team must check the village for environmental factors. Thirteen is intrigued by the patient's archaic standards of honor. Meanwhile, Wilson tries to reconcile with one of his ex-wives.
The team takes on the case of a woman living in an open marriage, who is stricken ill while dating her love. Meanwhile, House decides to determine if Sam is the woman for Wilson.
The team tries to diagnose a woman's fiancée, and she's surprised to learn the secrets that he's been keeping from her. Meanwhile, House decides to spend some musical free time with Chase and Foreman.
House tells Dr. Nolan about the case of a woman who had amnesia and a disease, and how he had to help solve both mysteries.
The team is called upon to aid a search-and-rescue operation during an emergency. House ends up staying to help a woman trapped beneath the rubble who has to choose whether she will sacrifice her imprisoned leg if she wants to live.
Now that they're together, House and Cuddy try to establish a normal relationship. Meanwhile, the team comes to the aid of an ailing Princeton neurosurgeon but discover that they need House's help... and House is nowhere to be found.
A family copes with a sick daughter and a dying son, and the team must diagnose the daughter before it's too late. Meanwhile, House deals with an elderly father and son, and tries to deal with the challenges of a workplace romance.
House and his team must treat both the physical and psychological ailments of a popular children's author when she collapses just moments before attempting suicide. When the diagnosis proves difficult, House becomes motivated as he believes the answer to her problems lie within her latest novel, which he happens to be a fan of. Meanwhile, House and Cuddy go on a double date with Sam and Wilson.
A patient is admitted to Princeton Plainsboro suffering from uncontrollable vomiting. In the process of treating her, House and the team make some unexpected discoveries about her identity and are forced to look at her medical history in order to learn the truth about her past. Meanwhile, House gives a less than friendly welcome to Chase's new hire and a visit from House's massage therapist causes trouble between House and Cuddy.
When an infant suffers breathing trouble and liver failure, House and the team must look at the medical history of the mother in order to find an answer, and ultimately land on a discovery that forces the mother to jeopardize not only her child's health but her own. Meanwhile, Taub and Foreman must find a new female doctor to fill the spot vacated by Thirteen, and House and Wilson learn a thing or two about parenting while caring for Cuddy's daughter.
When a campaign manager falls ill with liver failure and temporary paralysis in the midst of an election race, the team must look to the manager's candidate and his surprising announcement in order to solve the case. Meanwhile, Cuddy forces House to hire a new female doctor, one who has a past connection to Taub.
A girl is admitted to the hospital with smallpox, and the CDC institutes a lockdown. The doctor in charge forbids House's team from diagnosing, but Masters believes he has an ulterior motive. Meanwhile, Wilson and Sam reexamine their relationship while treating a young chemotherapy patient.
A patient is admitted to Princeton Plainsboro after reenacting the Crucifixion. Meanwhile House and the team attend a wedding, Wilson's relationship with Sam unexpectedly changes, and Taub questions his wife's relationship with a member of her infidelity support group.
House and the team must treat a man who collapsed after risking his life to save a stranger who fell onto the subway tracks, but it appears that there is more to this good deed than meets the eye. Meanwhile, House tries to avoid a birthday dinner with Cuddy and her mother, and Taub gains some unexpected attention and gets some help with his personal life from Martha Masters.
House and his team attempt to link the symptoms of a youth offender recruit and his disciplinary drillmaster. Meanwhile, House tries to help Cuddy's daughter Rachel get into a prestigious preschool, and Chase faces some personal troubles after a jilted sex partner starts pranking him.
When Cuddy's mother is admitted to Princeton Plainsboro and wants House off the case, House must come up with non-conventional methods to treat her. In the process he uncovers secrets which Arlene has hidden from Cuddy and her sister Lucinda. Meanwhile, House's methods to treat Cuddy's mother leads Masters to question her "by the book" stance on medicine, and Taub gets a second job from his ex-wife's brother that takes a toll on him.
Masters tries to mend the rift between a patient with perfect memory and her sister, when the patient's grudge threatens her treatment. Meanwhile, House tries to help Wilson get a date but discovers that his friend already has someone, and Foreman offers to help Taub study for an upcoming medical exam.
After House traumatizes a fifth-grade class with explicit medical stories during Career Day, he's sent to the principal's office and two students offer him relationship advice.
A patient is admitted to Princeton Plainsboro after breaking out in a rash caused by chemical exposure at his job. In the process of treating the patient, House and the team learns the man's wife still believes he runs a lucrative real estate business. Meanwhile, Chase and Masters teach each other a lesson in relationships and Cuddy is honored with an award. However, House may not make it to the ceremony when his patient causes him to rethink his practice and his happiness.
Cuddy faces sobering news that forces her to reevaluate her priorities, while a series of dreams show glimpses into her relationship with House and her life overall. Meanwhile, while House is preoccupied with Cuddy, the team treats a troubled teen whose worsening symptoms and body scars indicate that he may have more than just a physical illness.
A young professional champion bullfighter is admitted for treatment after being attacked by a bull. After conducting multiple inconclusive tests, the team enlists House's advice outside of the hospital while he attends to a few issues away from the case. Back in the hospital, the bullfighter's condition continues to worsen, but with disappearing symptoms and the patient's more frequent mini-seizures, the team's last option is risky open-heart surgery. Meanwhile, Masters develops a crush on their bullfighter patient much to Taub's surprise.
A homeless man with a history of drug abuse is admitted to Princeton Plainsboro with burns and scars on his chest. Meanwhile, Cuddy reveals her guilt to Wilson about breaking up with House.
House's encounter with an ex-employee who's disappeared for a whole year reveals some dark secrets. Along the way they travel to a spud-gun competition so House can do battle with a younger rival. Meanwhile, the team must find a cure for a science teacher suffering from respiratory distress whose house is filled with junk, and Taub tries his hand at dating.
House and the team treat a teenage girl who collapses just before embarking on a potentially record-breaking boating trip around the world. Meanwhile, Masters must decide if she wants to continue her schooling in order to become a surgeon or accept an offer to stay on House's team permanently. When their patient refuses a life-saving treatment that will keep her from setting the record, Masters makes a shocking decision.
The team treats a lottery winner who is stricken with partial paralysis. Meanwhile, Cuddy's mother sues the hospital, and Chase and Foreman make a bet with each other.
Rather than deal with his current case of a missile developer, House takes a boxer under his wing after trying to win a bet with Wilson, while the team suspects that House has a different drug problem.
Thirteen receives a visit from her former cellmate, and soon discovers that she is using drugs again. Unwilling to send her back to jail by taking her to the hospital and risking exposure, Thirteen asks Chase for help. Meanwhile, House and Taub both receive shocking news.
The team takes on the case of a performance artist, but soon suspect that she is causing her own symptoms as part of a new piece of "art." Meanwhile, House makes a choice that alter his relationship with his closest friends.
A year has passed since House ran Wilson's car into Cuddy's living room -- and House has spent most of it in prison. Now House only has to stay out of trouble for five days to win his parole. However, events conspire against him when a mysterious ailment strikes a fellow prisoner while a gang leader wants House to procure pills for him.
Foreman brings House back to Princeton Plainsboro under parole to deal with an infected pair of lungs needed for a transplant patient. House is forced to work with a timid intern, the loss of his former team, Wilson's hostility, and a new set of rules to find a cure in time to save the patient.
House and Park treat a patient, Benjamin, who collapsed after making a surprisingly large charity donation, and come to suspect that the altruistic behavior is a symptom of a deeper disorder. When the patient offers to donate an organ for another patient, the doctors must convince Thirteen to help them confirm whether Benjamin is in his right mind or not. Meanwhile, House cons Dr. Adams into volunteering her time as part of his team.
House attempts to negotiate with a wealthy patient who is planning to relocate his labor force to China. Meanwhile, Foreman chairs Park's disciplinary hearing, while Adams assesses her own ethics when she learns of their patient's relocation plans.
A community leader hiding dark secrets becomes ill and confesses everything... compromising his chances of receiving proper medical treatment when he antagonizes his friends and family. Meanwhile, House becomes obsessed with convincing Taub to prove that he's the father of his two six-month-old daughters.
House and his team treat a teenage boy who requires a bone marrow transplant, and discover a disturbing family secret. Meanwhile, Taub tries to cope with the fact that his ex-wife wants to take their new daughter and move cross-country, and House schemes to get rid of his ankle monitor and go to a boxing match.
A 14-year-old girl admitted for an allergic reaction gets increasingly worse. However, House would rather pursue the case of a deceased four-year-old and will go to any lengths to solve it... including going back to prison. Meanwhile, Park wonders why Chase is obsessed with personal grooming.
A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder. Also, Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell and Foreman's lack of romantic relationships piques the interest of Taub and Chase.
House and his team treat an Alzheimer's patient who flies into violent rages and throws up blood. Meanwhile, Wilson copies with a patient who claims that there is no sexual relationship in her marriage.
The team treats an underage and homeless female patient, but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict. But when her mother appears at her bedside, a more complicated relationship is revealed and the patient's mother must put the past aside and make the best decision for her daughter. Meanwhile, Taub has a difficult time connecting with his infant daughters and House threatens to exploit Foreman's relationship with a married woman.
When one of House's team is injured during an encounter with a violent patient, Foreman's mentor Dr. Walter Cofield reviews the incident and must sort out the truth from the embellishments.
Chase forms a bond with the team's newest patient, a cloistered nun ready to take her vows. Meanwhile, House and Taub engage in a war of pranks.
While the team treats a marriage counselor whose personality seems at odd with his motivational message, House and his green-card wife Dominika try to fool Immigration.
While House and his team treat a blind man, House's mother Blythe tells her son about her new relationship.
An Army veteran charged with treason is brought to the hospital for treatment, but refuses to cooperate unless the military give him and his brother information about their father. Meanwhile, Adams asks Wilson and her teammates for help when she suspects that House is concealing an illness
A 22-year old minor league hockey player collapses while fighting in the rink, and ends up at the hospital. Meanwhile, House surprises Wilson with some news and Chase offers to help Park with her living arrangements.
While the team treats a man who cries blood, House and Dominika team up to sabotage the relationship of Emily, his favorite prostitute, so that House doesn't have to go without.
While the team treats a boy who dreams that he's being choked and can't breath for real, the doctors consider the significance of dreams. Meanwhile, Dominika and House grow closer.
The team must deal with a doctor who is also the mother of their patient, a 6-year-old girl with numerous preexisting conditions on top of her current illness. Meanwhile, House and Wilson decide to take a vacation.
With House missing, the team must treat a pathologist at the hospital who trusts no one except House. To treat him, Chase and the others must convince their patient that House is still advising them.
While the team treats a college student who suffers from nosebleeds and hears his deceased brother speaking to him, Thirteen returns to Princeton and Foreman takes a different tack with House.
House treats a drug patient and is forced to examine his own life and confront his personal demons.